HitPredict

Interactor 1: CLH1 (Q00610)
Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17)
Gene: CLTC

Interactor 2: GGA1 (Q9UJY5)
ADP-ribosylation factor-binding protein GGA1 (Gamma-adaptin-related protein 1) (Golgi-localized, gamma ear-containing, ARF-binding protein 1)
Gene: GGA1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	1.00	0.906

Property	Details
Experiments	17052248, 11301005, 17344219, 17506864
Identification Methods	two hybrid, pull down, affinity chromatography technology, x-ray crystallography
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Alpha_adaptinC2~Clathrin
Common GO terms	GO:0005829 - cytosol GO:0006886 - intracellular protein transport GO:0016020 - membrane GO:0032991 - protein-containing complex GO:0042147 - retrograde transport, endosome to Golgi
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1675 Hs			1 639
+	Hs
		960999 CLH1_HUMAN (1-1675): 0: 3132: 100.00		GGA3_HUMAN (6-639): 3.76e-158: 473: 48.47
+	Hs
		961012 CLH1_HUMAN (1-1675): 0: 3132: 100.00		GGA2_HUMAN (3-637): 9.87e-155: 461: 46.78
+	Hs
		241163 CLH1_HUMAN (1-1675): 0: 3132: 100.00		TOM1_HUMAN (7-467): 2.18e-108: 337: 22.62
+	Hs
		960857 CLH1_HUMAN (1-1675): 0: 3132: 100.00		TM1L2_HUMAN (7-473): 1.61e-98: 312: 21.66
+	Hs
		212619 CLH1_HUMAN (1-1675): 0: 3132: 100.00		AP1G1_HUMAN (28-636): 1.9e-94: 310: 17.54
+	Hs
		960908 CLH1_HUMAN (1-1675): 0: 3132: 100.00		STAM1_HUMAN (3-519): 4.73e-90: 291: 16.05
+	Hs
		159961 CLH1_HUMAN (1-1675): 0: 3132: 100.00		HGS_HUMAN (5-478): 9.91e-85: 283: 17.40
+	Mm
		1148412 CLH1_MOUSE (1-1675): 0: 3131: 99.88		HGS_MOUSE (5-478): 3.64e-83: 279: 17.61
+	Mm
		1148410 CLH1_MOUSE (1-1675): 0: 3131: 99.88		TM1L1_MOUSE (7-466): 1.87e-78: 258: 17.06
+	Hs
		272801 CLH1_HUMAN (1-1675): 0: 3132: 100.00		TM1L1_HUMAN (7-461): 2.07e-74: 248: 19.23
+	Hs
		241158 CLH2_HUMAN (1-1634): 0: 2869: 85.01		TOM1_HUMAN (7-467): 2.18e-108: 337: 22.62
+	Dm
		669650 CLH_DROME (1-1663): 0: 2911: 80.17		Q9W329_DROME (10-620): 5.19e-90: 294: 24.92
+	Hs
		863981 CLH2_HUMAN (1-1634): 0: 2869: 85.01		STAM1_HUMAN (3-519): 4.73e-90: 291: 16.05
+	Zm
		25357 A0A1D6IQ85_MAIZE (6-1617): 0: 2658: 56.96		C4J1G1_MAIZE (15-581): 1.79e-82: 272: 17.18
+	Sc
		604404 CLH_YEAST (5-1648): 0: 2443: 49.79		GGA2_YEAST (2-633): 2.86e-93: 301: 20.71
+	Sc
		604476 CLH_YEAST (5-1648): 0: 2443: 49.79		GGA1_YEAST (2-440): 7.58e-79: 262: 20.79