HitPredict

Interactor 1: HSF1 (Q00613)
Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1)
Gene: HSF1

Interactor 2: HSF2 (Q03933)
Heat shock factor protein 2 (HSF 2) (Heat shock transcription factor 2) (HSTF 2)
Gene: HSF2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.95 1.00 0.979

The method score is based on:

Property Details
Experiments 26186194, 26496610, 28514442, 33961781, 12813038, 35271311, 25036637, 26727490
Identification Methods affinity chromatography technology, pull down, molecular sieving, anti tag coimmunoprecipitation, cross-linking study
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains HSF_DNA-bind~HSF_DNA-bind
Common GO terms GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001162 - RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
and 7 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 529
Hs

1 536
+ Hs
+ Hs
+ Hs
+ At
+ At
+ At
+ Dm
+ At
+ Ce
+ Tt
+ At
+ Hs
+ At
+ At
+ Sc
+ Os
+ Sc

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024