HitPredict

Interactor 1: NFKB2 (Q00653)
Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10 protein) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) (Oncogene Lyt-10) (Lyt10) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit]
Gene: NFKB2

Interactor 2: IKKE (Q14164)
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i)
Gene: IKBKE

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.42	1.00	0.653

Property	Details
Experiments	17003035
Identification Methods	two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank_2~Pkinase
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 900 Hs			1 716
+	Hs
		961442 NFKB2_HUMAN (1-900): 0: 713: 100.00		TBK1_HUMAN (1-714): 4.2e-162: 486: 48.13
+	Hs
		158446 NFKB2_HUMAN (1-900): 0: 713: 100.00		IKKB_HUMAN (9-701): 6.33e-128: 399: 18.97
+	Hs
		167522 NFKB2_HUMAN (1-900): 0: 713: 100.00		IKKA_HUMAN (9-700): 5.05e-116: 367: 18.31
+	Hs
		587739 NFKB1_HUMAN (6-881): 0: 586: 41.27		TBK1_HUMAN (1-714): 4.2e-162: 486: 48.13
+	Hs
		158394 NFKB1_HUMAN (6-881): 0: 586: 41.27		IKKB_HUMAN (9-701): 6.33e-128: 399: 18.97
+	Hs
		167469 NFKB1_HUMAN (6-881): 0: 586: 41.27		IKKA_HUMAN (9-700): 5.05e-116: 367: 18.31
+	Hs
		978751 TF65_HUMAN (24-354): 9.91e-113: 358: 40.96		IKKE_HUMAN (1-716): 1.32e-170: 508: 100.00
+	Hs
		981769 REL_HUMAN (33-456): 2.67e-112: 359: 33.88		TBK1_HUMAN (1-714): 4.2e-162: 486: 48.13
+	Hs
		978927 TF65_HUMAN (24-354): 9.91e-113: 358: 40.96		TBK1_HUMAN (1-714): 4.2e-162: 486: 48.13
+	Hs
		158452 REL_HUMAN (33-456): 2.67e-112: 359: 33.88		IKKB_HUMAN (9-701): 6.33e-128: 399: 18.97
+	Hs
		158450 TF65_HUMAN (24-354): 9.91e-113: 358: 40.96		IKKB_HUMAN (9-701): 6.33e-128: 399: 18.97
+	Mm
		291456 TF65_MOUSE (24-363): 1.01e-111: 355: 39.88		IKKB_MOUSE (9-701): 1.41e-126: 395: 19.10
+	Hs
		1284698 MIB2_HUMAN (404-803): 4.48e-74: 263: 21.59		TBK1_HUMAN (1-714): 4.2e-162: 486: 48.13
+	Hs
		167525 TF65_HUMAN (24-354): 9.91e-113: 358: 40.96		IKKA_HUMAN (9-700): 5.05e-116: 367: 18.31
+	Hs
		167523 RELB_HUMAN (27-356): 5.22e-89: 296: 39.34		IKKA_HUMAN (9-700): 5.05e-116: 367: 18.31
+	Hs
		167031 ANR28_HUMAN (290-588): 2.73e-33: 140: 17.59		TBK1_HUMAN (1-714): 4.2e-162: 486: 48.13
+	Hs
		1329540 TNKS2_HUMAN (395-805): 1.31e-40: 164: 17.24		TAOK2_HUMAN (2-702): 7.63e-113: 370: 15.59
+	Dm
		1276719 NFKB1_DROME (8-841): 2.36e-117: 382: 22.94		IKKB_DROME (1-317): 5.09e-29: 125: 31.77
+	Hs
		167471 BCL3_HUMAN (474-705): 5.69e-32: 132: 39.22		IKKA_HUMAN (9-700): 5.05e-116: 367: 18.31
+	Dm
		547642 DORS_DROME (7-361): 4.61e-92: 314: 34.89		IKKB_DROME (1-317): 5.09e-29: 125: 31.77