HitPredict

Interactor 1: NFKB2 (Q00653)
Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10 protein) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) (Oncogene Lyt-10) (Lyt10) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit]
Gene: NFKB2

Interactor 2: IKBD (Q8NI38)
NF-kappa-B inhibitor delta (NFKB inhibitor delta) (I-kappa-B-delta) (IkB-delta) (IkappaBdelta) (IkappaBNS) (T-cell activation NFKB-like protein) (TA-NFKBH)
Gene: NFKBID

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ank_2~Ank_2, Ank_2~Ank_5, Ank_2~RHD_dimer
Common GO terms	GO:0005634 - nucleus GO:0006954 - inflammatory response
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 900 Hs			1 313
+	Hs
		961435 NFKB2_HUMAN (1-900): 0: 713: 100.00		IKBZ_HUMAN (26-309): 2.66e-88: 280: 42.14
+	Hs
		595669 NFKB2_HUMAN (1-900): 0: 713: 100.00		BCL3_HUMAN (9-312): 4.63e-59: 197: 28.34
+	Hs
		587698 NFKB1_HUMAN (6-881): 0: 586: 41.27		IKBZ_HUMAN (26-309): 2.66e-88: 280: 42.14
+	Mm
		1322368 NFKB2_MOUSE (1-900): 0: 727: 91.78		IKBZ_MOUSE (1-182): 1.47e-24: 105: 15.60
+	Mm
		638473 NFKB2_MOUSE (1-900): 0: 727: 91.78		NFKB1_MOUSE (189-308): 2.16e-12: 69.8: 30.33
+	Hs
		587641 NFKB1_HUMAN (6-881): 0: 586: 41.27		IKBD_HUMAN (1-313): 8.33e-66: 210: 100.00
+	Hs
		587410 NFKB1_HUMAN (6-881): 0: 586: 41.27		BCL3_HUMAN (9-312): 4.63e-59: 197: 28.34
+	Hs
		587527 NFKB2_HUMAN (1-900): 0: 713: 100.00		NFKB1_HUMAN (160-307): 2.1e-12: 69.8: 26.32
+	Hs
		961363 NFKB2_HUMAN (1-900): 0: 713: 100.00		NFKB2_HUMAN (183-311): 7.93e-12: 67.8: 24.81
+	Hs
		639729 NFKB2_HUMAN (1-900): 0: 713: 100.00		IKBA_HUMAN (47-228): 7.74e-11: 63.9: 30.57
+	Hs
		121583 NFKB2_HUMAN (1-900): 0: 713: 100.00		IKBE_HUMAN (118-305): 8.98e-10: 61.3: 22.05
+	Hs
		587628 NFKB1_HUMAN (6-881): 0: 586: 41.27		ANKH1_HUMAN (1-233): 2.5e-40: 152: 17.63
+	Mm
		638472 NFKB1_MOUSE (6-881): 0: 603: 41.91		IKBZ_MOUSE (1-182): 1.47e-24: 105: 15.60
+	Mm
		638435 NFKB1_MOUSE (6-881): 0: 603: 41.91		NFKB1_MOUSE (189-308): 2.16e-12: 69.8: 30.33
+	Hs
		587408 NFKB1_HUMAN (6-881): 0: 586: 41.27		NFKB1_HUMAN (160-307): 2.1e-12: 69.8: 26.32
+	Hs
		587427 NFKB1_HUMAN (6-881): 0: 586: 41.27		IKBA_HUMAN (47-228): 7.74e-11: 63.9: 30.57
+	Hs
		276140 NFKB1_HUMAN (6-881): 0: 586: 41.27		PSD10_HUMAN (82-293): 1.11e-10: 62.4: 29.11
+	Hs
		121567 NFKB1_HUMAN (6-881): 0: 586: 41.27		IKBE_HUMAN (118-305): 8.98e-10: 61.3: 22.05