HitPredict

Interactor 1: NFKB2 (Q00653)
Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10 protein) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) (Oncogene Lyt-10) (Lyt10) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit]
Gene: NFKB2

Interactor 2: FBXW7 (Q969H0)
F-box/WD repeat-containing protein 7 (Archipelago homolog) (hAgo) (F-box and WD-40 domain-containing protein 7) (F-box protein FBX30) (SEL-10) (hCdc4)
Gene: FBXW7

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	0.60	0.724

Property	Details
Experiments	14743216, 22388891, 22864569, 25720964, 32350066, 33658012
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0048511 - rhythmic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 900 Hs			1 707
+	Hs
		587665 NFKB1_HUMAN (6-881): 0: 586: 41.27		FBXW7_HUMAN (1-707): 0: 571: 100.00
+	Hs
		978839 TF65_HUMAN (24-354): 9.91e-113: 358: 40.96		FBXW7_HUMAN (1-707): 0: 571: 100.00
+	Hs
		964515 RELB_HUMAN (27-356): 5.22e-89: 296: 39.34		FBXW7_HUMAN (1-707): 0: 571: 100.00
+	Mm
		1112931 NFKB2_MOUSE (1-900): 0: 727: 91.78		FBW1A_MOUSE (614-705): 1.6e-11: 69.7: 26.09
+	Hs
		961451 NFKB2_HUMAN (1-900): 0: 713: 100.00		FBW1A_HUMAN (614-705): 2.9e-12: 72: 26.09
+	Hs
		961443 NFKB2_HUMAN (1-900): 0: 713: 100.00		FBW1B_HUMAN (614-705): 7.05e-12: 70.5: 25.00
+	Hs
		1219809 ANKH1_HUMAN (624-876): 1.11e-32: 139: 20.60		FBXW7_HUMAN (1-707): 0: 571: 100.00
+	Hs
		639784 IKBA_HUMAN (486-677): 9.26e-26: 110: 39.38		FBXW7_HUMAN (1-707): 0: 571: 100.00
+	Hs
		587758 NFKB1_HUMAN (6-881): 0: 586: 41.27		FBW1A_HUMAN (614-705): 2.9e-12: 72: 26.09
+	Hs
		587745 NFKB1_HUMAN (6-881): 0: 586: 41.27		FBW1B_HUMAN (614-705): 7.05e-12: 70.5: 25.00
+	Hs
		978931 TF65_HUMAN (24-354): 9.91e-113: 358: 40.96		FBXW2_HUMAN (574-692): 2.05e-17: 87.3: 26.89
+	Hs
		981788 REL_HUMAN (33-456): 2.67e-112: 359: 33.88		FBW1A_HUMAN (614-705): 2.9e-12: 72: 26.09
+	Hs
		978943 TF65_HUMAN (24-354): 9.91e-113: 358: 40.96		FBW1A_HUMAN (614-705): 2.9e-12: 72: 26.09
+	Hs
		978930 TF65_HUMAN (24-354): 9.91e-113: 358: 40.96		FBW1B_HUMAN (614-705): 7.05e-12: 70.5: 25.00
+	Hs
		166894 ANR28_HUMAN (290-588): 2.73e-33: 140: 17.59		LIS1_HUMAN (457-706): 3.92e-66: 225: 27.08
+	Hs
		595684 BCL3_HUMAN (474-705): 5.69e-32: 132: 39.22		TBL1R_HUMAN (251-570): 8.42e-66: 228: 18.58
+	Hs
		903354 ANKH1_HUMAN (624-876): 1.11e-32: 139: 20.60		WDR5_HUMAN (570-706): 2.64e-27: 115: 23.02
+	Mm
		222603 IKBE_MOUSE (477-701): 1.51e-29: 123: 39.39		FBW1A_MOUSE (614-705): 1.6e-11: 69.7: 26.09
+	Hs
		121606 IKBE_HUMAN (472-704): 4.58e-25: 112: 38.98		FBW1A_HUMAN (614-705): 2.9e-12: 72: 26.09
+	Hs
		121601 IKBE_HUMAN (472-704): 4.58e-25: 112: 38.98		FBW1B_HUMAN (614-705): 7.05e-12: 70.5: 25.00