HitPredict

Interactor 1: REEP5 (Q00765)
Receptor expression-enhancing protein 5 (Polyposis locus protein 1) (Protein TB2)
Gene: REEP5

Interactor 2: ESYT1 (Q9BSJ8)
Extended synaptotagmin-1 (E-Syt1) (Membrane-bound C2 domain-containing protein)
Gene: ESYT1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.694

Property	Details
Experiments	34079125, 33961781, 35271311, 37931956
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005783 - endoplasmic reticulum
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 189 Hs			1 1104
+	Hs
		1311396 REEP4_HUMAN (56-177): 2.22e-49: 162: 36.07		ESYT1_HUMAN (1-1104): 0: 874: 100.00
+	Hs
		48335 REEP5_HUMAN (1-189): 3.52e-89: 261: 100.00		ESYT2_HUMAN (848-1101): 9e-14: 78.1: 12.32
+	Hs
		48511 REEP4_HUMAN (56-177): 2.22e-49: 162: 36.07		ESYT2_HUMAN (848-1101): 9e-14: 78.1: 12.32
+	Hs
		48480 REEP2_HUMAN (54-176): 1.22e-48: 160: 34.15		ESYT2_HUMAN (848-1101): 9e-14: 78.1: 12.32