HitPredict

Interactor 1: REEP5 (Q00765)
Receptor expression-enhancing protein 5 (Polyposis locus protein 1) (Protein TB2)
Gene: REEP5

Interactor 2: RTN4 (Q9NQC3)
Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5)
Gene: RTN4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	34079125, 33961781, 35271311
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005783 - endoplasmic reticulum GO:0007029 - endoplasmic reticulum organization GO:0071782 - endoplasmic reticulum tubular network
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 189 Hs			1 1192
+	Hs
		1332293 REEP4_HUMAN (56-177): 2.22e-49: 162: 36.07		RTN4_HUMAN (1-1192): 3.85e-113: 383: 100.00
+	Hs
		307022 REEP5_HUMAN (1-189): 3.52e-89: 261: 100.00		RTN3_HUMAN (269-1191): 7.4e-55: 210: 22.06
+	Hs
		961671 REEP5_HUMAN (1-189): 3.52e-89: 261: 100.00		RTN1_HUMAN (419-1192): 1e-50: 194: 23.36
+	Hs
		307091 REEP6_HUMAN (4-177): 7.33e-77: 230: 58.05		RTN3_HUMAN (269-1191): 7.4e-55: 210: 22.06
+	Hs
		258920 REEP5_HUMAN (1-189): 3.52e-89: 261: 100.00		RTN2_HUMAN (775-1185): 4.86e-44: 171: 25.39
+	Hs
		307124 REEP4_HUMAN (56-177): 2.22e-49: 162: 36.07		RTN3_HUMAN (269-1191): 7.4e-55: 210: 22.06