Interactor 1: MDM2 (Q00987)
E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2)
Gene: MDM2
Interactor 2: HIPK2 (Q9H2X6)
Homeodomain-interacting protein kinase 2 (hHIPk2) (EC 2.7.11.1)
Gene: HIPK2
Species: Homo sapiens
Source: mint
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.78 | 0.60 | 0.686 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 16212962, 17349959, 23826318 |
| Identification Methods | affinity chromatography technology, enzymatic study, anti bait coimmunoprecipitation, pull down, anti tag coimmunoprecipitation, experimental interaction detection |
| Interaction Type | physical association, direct interaction, phosphorylation reaction |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | - |
| Common GO terms | GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0008284 - positive regulation of cell population proliferation and 2 others more... |
| Homologous interactions | 8 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
