HitPredict

Interactor 1: MDM2 (Q00987)
E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2)
Gene: MDM2

Interactor 2: NOP53 (Q9NZM5)
Ribosome biogenesis protein NOP53 (Glioma tumor suppressor candidate region gene 2 protein) (Protein interacting with carboxyl terminus 1) (PICT-1) (p60)
Gene: NOP53

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.55	0.588

The method score is based on:

Property	Details
Experiments	33961781, 21988832
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0002039 - p53 binding GO:0005654 - nucleoplasm GO:0005730 - nucleolus GO:0005829 - cytosol and 5 others more... GO:0008097 - 5S rRNA binding GO:0032436 - positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0051726 - regulation of cell cycle GO:0071456 - cellular response to hypoxia GO:1901797 - negative regulation of signal transduction by p53 class mediator
Homologous interactions	0

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Last updated: 15 Jul 2024