HitPredict

Interactor 1: U2AF1 (Q01081)
Splicing factor U2AF 35 kDa subunit (U2 auxiliary factor 35 kDa subunit) (U2 small nuclear RNA auxiliary factor 1) (U2 snRNP auxiliary factor small subunit)
Gene: U2AF1

Interactor 2: RNPS1 (Q15287)
RNA-binding protein with serine-rich domain 1 (SR-related protein LDC2)
Gene: RNPS1

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.70	1.00	0.837

Property	Details
Experiments	25416956, 22365833, 17353931
Identification Methods	two hybrid, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1, RRM_1~zf-CCCH
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0008380 - RNA splicing GO:0016607 - nuclear speck
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 240 Hs			1 305
+	Hs
		88033 U2AF1_HUMAN (1-186): 2.02e-105: 306: 100.00		D3DU92_HUMAN (1-234): 2e-34: 128: 100.00
+	Hs
		853861 U2AF1_HUMAN (1-186): 2.02e-105: 306: 100.00		NCBP2_HUMAN (128-271): 1.08e-30: 114: 18.06
+	Hs
		1259757 U2AF4_HUMAN (1-186): 4.86e-98: 286: 84.95		PPIE_HUMAN (159-297): 4.41e-33: 125: 17.73
+	Hs
		516470 U2AF1_HUMAN (1-186): 2.02e-105: 306: 100.00		PABP1_HUMAN (65-252): 1.33e-21: 96.9: 16.32