HitPredict

Interactor 1: SPTB2 (Q01082)
Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1)
Gene: SPTBN1

Interactor 2: DYR1A (Q13627)
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.11.23) (EC 2.7.12.1) (Dual specificity YAK1-related kinase) (HP86) (Protein kinase minibrain homolog) (MNBH) (hMNB)
Gene: DYRK1A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.614

Property	Details
Experiments	30979931, 35914814
Identification Methods	affinity chromatography technology, two hybrid, two hybrid fragment pooling approach
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003779 - actin binding GO:0005737 - cytoplasm
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 2364 Hs			1 763
+	Hs
		625369 SPTB2_HUMAN (1-2364): 0: 751: 100.00		CDK2_HUMAN (156-420): 1.05e-117: 358: 26.85
+	Hs
		1043778 SPTN1_HUMAN (152-1087): 9.93e-19: 96.3: 16.89		DYR1A_HUMAN (1-763): 0: 613: 100.00
+	Hs
		809114 UTRN_HUMAN (212-2073): 1e-17: 93.2: 10.02		DYR1A_HUMAN (1-763): 0: 613: 100.00
+	Hs
		521469 ACTN1_HUMAN (28-775): 4.31e-92: 323: 34.25		CDK2_HUMAN (156-420): 1.05e-117: 358: 26.85
+	Ce
		1376849 Q9XVU8_CAEEL (33-780): 1.47e-85: 304: 34.38		MBK2_CAEEL (82-494): 4.42e-113: 363: 39.47
+	Hs
		647842 UTRN_HUMAN (212-2073): 1e-17: 93.2: 10.02		MARK3_HUMAN (105-758): 1.17e-123: 389: 17.72
+	Hs
		647985 MACF1_HUMAN (687-1920): 4.98e-16: 87.6: 12.23		MARK3_HUMAN (105-758): 1.17e-123: 389: 17.72
+	Hs
		625380 DYST_HUMAN (537-1421): 8.42e-22: 106: 12.00		CDK2_HUMAN (156-420): 1.05e-117: 358: 26.85
+	Hs
		625418 SPTN1_HUMAN (152-1087): 9.93e-19: 96.3: 16.89		CDK2_HUMAN (156-420): 1.05e-117: 358: 26.85
+	Hs
		625446 PLEC_HUMAN (222-1144): 1.08e-16: 89.7: 11.59		CDK2_HUMAN (156-420): 1.05e-117: 358: 26.85