HitPredict

Interactor 1: SPTB2 (Q01082)
Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1)
Gene: SPTBN1

Interactor 2: SPTN1 (Q13813)
Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit)
Gene: SPTAN1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.89 1.00 0.943

The method score is based on:

Property Details
Experiments 30021884, 37071682, 17607528, 35235311, 12820899, 17088250
Identification Methods proximity labelling technology, cross-linking study, two hybrid, pull down, surface plasmon resonance
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains CH~EF-hand_7, CH~EFhand_Ca_insen, CH~Spectrin, EFhand_Ca_insen~Spectrin, Spectrin~Spectrin
Common GO terms GO:0003779 - actin binding
GO:0005200 - structural constituent of cytoskeleton
GO:0005516 - calmodulin binding
GO:0005829 - cytosol
GO:0005886 - plasma membrane
and 9 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

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Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024