HitPredict

Interactor 1: E2F1 (Q01094)
Transcription factor E2F1 (E2F-1) (PBR3) (Retinoblastoma-associated protein 1) (RBAP-1) (Retinoblastoma-binding protein 3) (RBBP-3) (pRB-binding protein E2F-1)
Gene: E2F1

Interactor 2: BIRC2 (Q13490)
Baculoviral IAP repeat-containing protein 2 (EC 2.3.2.27) (Cellular inhibitor of apoptosis 1) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (hIAP-2) (hIAP2) (RING finger protein 48) (RING-type E3 ubiquitin transferase BIRC2) (TNFR2-TRAF-signaling complex protein 2)
Gene: BIRC2

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.681

Property	Details
Experiments	28542143, 30359437, 21653699
Identification Methods	enzymatic study, affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 437 Hs			1 618
+	Hs
		963609 E2F1_HUMAN (1-437): 2.41e-171: 489: 100.00		BIRC3_HUMAN (5-259): 2.61e-52: 191: 28.03
+	Hs
		962734 E2F1_HUMAN (1-437): 2.41e-171: 489: 100.00		MDM2_HUMAN (344-617): 6.07e-34: 137: 15.56
+	Hs
		957685 E2F1_HUMAN (1-437): 2.41e-171: 489: 100.00		XIAP_HUMAN (17-173): 6.46e-31: 128: 29.38
+	Hs
		135266 E2F3_HUMAN (39-433): 1.86e-129: 383: 41.69		MIB1_HUMAN (231-616): 1.49e-51: 193: 15.83
+	Hs
		1071524 E2F5_HUMAN (125-426): 1.6e-100: 305: 33.55		MIB1_HUMAN (231-616): 1.49e-51: 193: 15.83
+	Hs
		265675 E2F6_HUMAN (56-342): 6.21e-97: 294: 33.91		MIB1_HUMAN (231-616): 1.49e-51: 193: 15.83
+	Hs
		1081306 E2F4_HUMAN (126-394): 2.19e-81: 258: 33.45		MIB1_HUMAN (231-616): 1.49e-51: 193: 15.83