HitPredict

Interactor 1: NMDE2 (Q01097)
Glutamate receptor ionotropic, NMDA 2B (GluN2B) (Glutamate [NMDA] receptor subunit epsilon-2) (N-methyl D-aspartate receptor subtype 2B) (NMDAR2B) (NR2B)
Gene: Grin2b

Interactor 2: DAPK1 (Q80YE7)
Death-associated protein kinase 1 (DAP kinase 1) (EC 2.7.11.1)
Gene: DAPK1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.633

Property	Details
Experiments	31914378, 20141836
Identification Methods	pull down, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0014069 - postsynaptic density GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1482 Mm			1 1442
+	Mm
		723597 NMDZ1_MOUSE (14-940): 0: 681: 23.41		DAPK1_MOUSE (1-1442): 0: 2004: 100.00
+	Mm
		515226 NMDE2_MOUSE (1-1482): 0: 1874: 100.00		KCC2A_MOUSE (1-383): 1.5e-117: 379: 29.17
+	Rn
		550161 NMDE2_RAT (1-1482): 0: 1873: 99.46		KCC2D_RAT (8-347): 1.82e-117: 380: 31.97
+	Rn
		506719 NMDE2_RAT (1-1482): 0: 1873: 99.46		KCC2A_RAT (1-383): 1.5e-117: 379: 29.17
+	Hs
		1028155 NMDE2_HUMAN (1-1482): 0: 1855: 98.38		KCC2A_HUMAN (1-383): 1.64e-117: 378: 29.17
+	Mm
		57819 G3X9V4_MOUSE (1-1482): 0: 1876: 99.93		KALRN_MOUSE (2-312): 1.28e-60: 232: 38.26
+	Mm
		57838 NMDE2_MOUSE (1-1482): 0: 1874: 100.00		KALRN_MOUSE (2-312): 1.28e-60: 232: 38.26
+	Rn
		957072 NMDE2_RAT (1-1482): 0: 1873: 99.46		KALRN_RAT (2-312): 1.19e-60: 232: 38.26
+	Rn
		550160 NMDE1_RAT (9-1482): 0: 1521: 52.58		KCC2D_RAT (8-347): 1.82e-117: 380: 31.97
+	Rn
		506718 NMDE1_RAT (9-1482): 0: 1521: 52.58		KCC2A_RAT (1-383): 1.5e-117: 379: 29.17
+	Rn
		957071 NMDE1_RAT (9-1482): 0: 1521: 52.58		KALRN_RAT (2-312): 1.19e-60: 232: 38.26
+	Rn
		506693 GRIA1_RAT (12-901): 0: 685: 20.04		KCC2A_RAT (1-383): 1.5e-117: 379: 29.17
+	Hs
		786716 GRIA1_HUMAN (12-901): 0: 685: 19.96		KCC2A_HUMAN (1-383): 1.64e-117: 378: 29.17
+	Mm
		515217 NMDZ1_MOUSE (14-940): 0: 681: 23.41		KCC2A_MOUSE (1-383): 1.5e-117: 379: 29.17
+	Hs
		984288 NMDZ1_HUMAN (14-940): 0: 678: 23.52		KCC2A_HUMAN (1-383): 1.64e-117: 378: 29.17
+	Hs
		224704 GRIK1_HUMAN (1-854): 0: 724: 20.26		KALRN_HUMAN (2-312): 7.57e-61: 233: 38.59
+	Rn
		585146 GRIA1_RAT (12-901): 0: 685: 20.04		KALRN_RAT (2-312): 1.19e-60: 232: 38.26
+	Mm
		57832 NMDZ1_MOUSE (14-940): 0: 681: 23.41		KALRN_MOUSE (2-312): 1.28e-60: 232: 38.26
+	Mm
		57829 GRIA2_MOUSE (8-871): 0: 674: 21.16		KALRN_MOUSE (2-312): 1.28e-60: 232: 38.26
+	Hs
		984274 NMDZ1_HUMAN (14-940): 0: 678: 23.52		ANKK1_HUMAN (641-964): 1.88e-22: 106: 12.43