HitPredict

Interactor 1: CDC42 (Q01112)
Cell division control protein 42 homolog (CDC42Sp)
Gene: CDC42

Interactor 2: SHK2 (Q10056)
Serine/threonine-protein kinase shk2 (EC 2.7.11.1)
Gene: SHK2

Species: Schizosaccharomyces pombe 972h-

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.80	0.674

Property	Details
Experiments	9660817, 9660818
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PBD~Ras, PH~Ras, Pkinase~Ras
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Sp			1 589
+	Hs
		564505 RHOQ_HUMAN (4-190): 1.13e-87: 258: 64.74		PAK1_HUMAN (47-589): 2.02e-147: 437: 36.32
+	Hs
		564507 RHOQ_HUMAN (4-190): 1.13e-87: 258: 64.74		PAK2_HUMAN (62-589): 7.82e-146: 433: 36.86
+	Mm
		103566 RAC1_MOUSE (1-192): 3.29e-83: 246: 68.23		G5E884_MOUSE (48-589): 1.67e-147: 438: 36.27
+	Hs
		277602 RAC1_HUMAN (1-192): 3.29e-83: 246: 68.23		PAK3_HUMAN (60-585): 2.03e-147: 438: 35.29
+	Hs
		925244 RAC1_HUMAN (1-192): 3.29e-83: 246: 68.23		PAK1_HUMAN (47-589): 2.02e-147: 437: 36.32
+	Mm
		925809 RAC1_MOUSE (1-192): 3.29e-83: 246: 68.23		PAK2_MOUSE (62-589): 1.44e-146: 435: 36.86
+	Hs
		277619 RHOJ_HUMAN (4-189): 7.92e-81: 241: 61.83		PAK3_HUMAN (60-585): 2.03e-147: 438: 35.29
+	Hs
		925245 RAC1_HUMAN (1-192): 3.29e-83: 246: 68.23		PAK2_HUMAN (62-589): 7.82e-146: 433: 36.86
+	Hs
		1026226 RHOJ_HUMAN (4-189): 7.92e-81: 241: 61.83		PAK1_HUMAN (47-589): 2.02e-147: 437: 36.32
+	Mm
		292040 RAC1_MOUSE (1-192): 3.29e-83: 246: 68.23		PAK1_MOUSE (48-589): 2.67e-145: 432: 35.84
+	Hs
		1026945 RHOJ_HUMAN (4-189): 7.92e-81: 241: 61.83		PAK2_HUMAN (62-589): 7.82e-146: 433: 36.86
+	Hs
		564425 RHOQ_HUMAN (4-190): 1.13e-87: 258: 64.74		AKT2_HUMAN (164-589): 1.89e-133: 400: 19.78
+	Hs
		681775 RAC1_HUMAN (1-192): 3.29e-83: 246: 68.23		AKT1_HUMAN (160-589): 2.27e-133: 399: 19.91
+	Hs
		330841 RHOQ_HUMAN (4-190): 1.13e-87: 258: 64.74		PAK4_HUMAN (191-583): 1.8e-120: 370: 35.80
+	Ce
		975572 RAC1_CAEEL (1-192): 1.18e-81: 241: 66.15		PK1_CAEEL (74-583): 2.4e-127: 387: 34.16
+	Hs
		330967 RAC1_HUMAN (1-192): 3.29e-83: 246: 68.23		PAK4_HUMAN (191-583): 1.8e-120: 370: 35.80
+	Hs
		331085 RHOJ_HUMAN (4-189): 7.92e-81: 241: 61.83		PAK4_HUMAN (191-583): 1.8e-120: 370: 35.80
+	Hs
		925692 RAC1_HUMAN (1-192): 3.29e-83: 246: 68.23		PAK5_HUMAN (110-583): 7.72e-116: 362: 28.68
+	Hs
		925648 RAC1_HUMAN (1-192): 3.29e-83: 246: 68.23		PAK6_HUMAN (287-579): 4.61e-73: 248: 44.56
+	Hs
		1330933 RHOJ_HUMAN (4-189): 7.92e-81: 241: 61.83		PAK6_HUMAN (287-579): 4.61e-73: 248: 44.56