HitPredict

Interactor 1: SRSF2 (Q01130)
Serine/arginine-rich splicing factor 2 (Protein PR264) (Splicing component, 35 kDa) (Splicing factor SC35) (SC-35) (Splicing factor, arginine/serine-rich 2)
Gene: SRSF2

Interactor 2: SRSF4 (Q08170)
Serine/arginine-rich splicing factor 4 (Pre-mRNA-splicing factor SRP75) (SRP001LB) (Splicing factor, arginine/serine-rich 4)
Gene: SRSF4

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.775

Property	Details
Experiments	22365833, 37071682
Identification Methods	two hybrid, cross-linking study
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006397 - mRNA processing and 2 others more... GO:0008380 - RNA splicing GO:0016607 - nuclear speck
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 221 Hs			1 494
+	Hs
		1028926 SF3B4_HUMAN (4-205): 1.41e-52: 176: 17.24		SRSF6_HUMAN (1-180): 4.52e-52: 181: 78.50
+	Hs
		516478 PABP1_HUMAN (6-202): 1.69e-41: 150: 18.27		SRSF1_HUMAN (3-166): 2.36e-57: 192: 41.42
+	Hs
		963969 SRSF2_HUMAN (1-221): 1.22e-43: 147: 100.00		SRSF1_HUMAN (3-166): 2.36e-57: 192: 41.42
+	Hs
		516493 PABP1_HUMAN (6-202): 1.69e-41: 150: 18.27		SRSF9_HUMAN (3-216): 2.36e-52: 178: 36.53
+	Hs
		992743 ELAV2_HUMAN (1-195): 6.01e-38: 136: 15.79		SRSF1_HUMAN (3-166): 2.36e-57: 192: 41.42
+	Hs
		963976 SRSF2_HUMAN (1-221): 1.22e-43: 147: 100.00		SRSF5_HUMAN (3-256): 1.26e-49: 172: 53.85
+	Hs
		1020247 ELAV2_HUMAN (1-195): 6.01e-38: 136: 15.79		SRSF6_HUMAN (1-180): 4.52e-52: 181: 78.50
+	Hs
		1029063 SRSF8_HUMAN (1-183): 4.13e-29: 111: 63.39		SRSF6_HUMAN (1-180): 4.52e-52: 181: 78.50
+	Hs
		993814 SRSF8_HUMAN (1-183): 4.13e-29: 111: 63.39		SRSF4_HUMAN (1-468): 4.56e-48: 174: 100.00
+	Hs
		1028792 SRSF8_HUMAN (1-183): 4.13e-29: 111: 63.39		SRSF5_HUMAN (3-256): 1.26e-49: 172: 53.85
+	Hs
		516339 PABP1_HUMAN (6-202): 1.69e-41: 150: 18.27		PABP1_HUMAN (1-189): 4.04e-31: 128: 19.50
+	Hs
		516689 PABP1_HUMAN (6-202): 1.69e-41: 150: 18.27		PABP3_HUMAN (3-189): 1.09e-28: 121: 19.19
+	Hs
		516484 ELAV2_HUMAN (1-195): 6.01e-38: 136: 15.79		PABP1_HUMAN (1-189): 4.04e-31: 128: 19.50
+	Hs
		516495 PABP1_HUMAN (6-202): 1.69e-41: 150: 18.27		PABP4_HUMAN (100-185): 3.19e-11: 67.7: 19.78
+	Zm
		30171 A0A1D6K4S7_MAIZE (3-93): 2.97e-41: 146: 47.83		A0A1D6M1U3_MAIZE (100-205): 2e-12: 70.4: 17.59
+	Hs
		516471 PABP1_HUMAN (6-202): 1.69e-41: 150: 18.27		TIAR_HUMAN (96-188): 2.66e-10: 63.8: 16.67
+	Mm
		665745 PABP1_MOUSE (6-202): 2.07e-41: 150: 18.27		TIA1_MOUSE (98-188): 7.57e-10: 62.7: 17.02
+	Mm
		857332 SRSF2_MOUSE (1-221): 1.22e-43: 147: 100.00		TIA1_MOUSE (98-188): 7.57e-10: 62.7: 17.02
+	Hs
		1020249 ELAV2_HUMAN (1-195): 6.01e-38: 136: 15.79		PABP4_HUMAN (100-185): 3.19e-11: 67.7: 19.78
+	Hs
		474019 ELAV2_HUMAN (1-195): 6.01e-38: 136: 15.79		PAB4L_HUMAN (100-185): 1.44e-10: 65: 19.78