HitPredict

Interactor 1: SRSF2 (Q01130)
Serine/arginine-rich splicing factor 2 (Protein PR264) (Splicing component, 35 kDa) (Splicing factor SC35) (SC-35) (Splicing factor, arginine/serine-rich 2)
Gene: SRSF2

Interactor 2: ESR2 (Q92731)
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
Gene: ESR2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	29509190, 21182203, 25604459
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 221 Hs			1 530
+	Hs
		1073609 SF3B4_HUMAN (4-205): 1.41e-52: 176: 17.24		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		369664 SF3B4_HUMAN (4-205): 1.41e-52: 176: 17.24		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		1031409 PABP4_HUMAN (5-191): 4.16e-25: 104: 13.37		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		368886 PABP1_HUMAN (6-202): 1.69e-41: 150: 18.27		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		1269600 PABP3_HUMAN (15-221): 2.48e-24: 101: 16.91		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		369424 SRSF2_HUMAN (1-221): 1.22e-43: 147: 100.00		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		1269332 PABP5_HUMAN (16-95): 2.11e-18: 84.4: 21.25		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		680471 TIA1_HUMAN (9-184): 2.34e-16: 78.5: 10.67		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		369534 PABP4_HUMAN (5-191): 4.16e-25: 104: 13.37		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		370422 PABP3_HUMAN (15-221): 2.48e-24: 101: 16.91		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		370176 PABP5_HUMAN (16-95): 2.11e-18: 84.4: 21.25		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		369064 TIA1_HUMAN (9-184): 2.34e-16: 78.5: 10.67		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Mm
		509289 PABP1_MOUSE (6-202): 2.07e-41: 150: 18.27		RARA_MOUSE (52-508): 5.87e-105: 324: 23.58
+	Hs
		516359 PABP1_HUMAN (6-202): 1.69e-41: 150: 18.27		NR4A1_HUMAN (7-501): 3.18e-101: 318: 25.30
+	Hs
		377286 ELAV2_HUMAN (1-195): 6.01e-38: 136: 15.79		GCR_HUMAN (3-495): 1.12e-103: 330: 22.64
+	Hs
		782537 PABP4_HUMAN (5-191): 4.16e-25: 104: 13.37		HNF4A_HUMAN (94-502): 1.21e-107: 331: 23.30
+	Hs
		611434 PABP4_HUMAN (5-191): 4.16e-25: 104: 13.37		NR4A1_HUMAN (7-501): 3.18e-101: 318: 25.30
+	Hs
		487081 PABP1_HUMAN (6-202): 1.69e-41: 150: 18.27		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		414527 PUF60_HUMAN (8-108): 1.34e-23: 100: 23.76		PRGR_HUMAN (149-459): 2.26e-41: 161: 32.82
+	Hs
		487822 PUF60_HUMAN (8-108): 1.34e-23: 100: 23.76		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59