HitPredict

Interactor 1: SRSF2 (Q01130)
Serine/arginine-rich splicing factor 2 (Protein PR264) (Splicing component, 35 kDa) (Splicing factor SC35) (SC-35) (Splicing factor, arginine/serine-rich 2)
Gene: SRSF2

Interactor 2: SRSF8 (Q9BRL6)
Serine/arginine-rich splicing factor 8 (Pre-mRNA-splicing factor SRP46) (Splicing factor SRp46) (Splicing factor, arginine/serine-rich 2B)
Gene: SRSF8

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34349018
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0005681 - spliceosomal complex GO:0005829 - cytosol and 1 others more... GO:0016607 - nuclear speck
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 221 Hs			1 282
+	Hs
		963965 SRSF2_HUMAN (1-221): 1.22e-43: 147: 100.00		SRSF2_HUMAN (1-100): 1.3e-41: 144: 80.00
+	Hs
		1020321 ELAV2_HUMAN (1-195): 6.01e-38: 136: 15.79		SRSF8_HUMAN (1-282): 5.34e-41: 144: 100.00
+	Hs
		516744 PABP1_HUMAN (6-202): 1.69e-41: 150: 18.27		PPIE_HUMAN (16-102): 3.36e-32: 122: 35.63
+	Hs
		964080 SRSF2_HUMAN (1-221): 1.22e-43: 147: 100.00		PPIE_HUMAN (16-102): 3.36e-32: 122: 35.63
+	Hs
		1020353 ELAV2_HUMAN (1-195): 6.01e-38: 136: 15.79		PPIE_HUMAN (16-102): 3.36e-32: 122: 35.63
+	Hs
		516484 PABP1_HUMAN (6-202): 1.69e-41: 150: 18.27		ELAV2_HUMAN (2-99): 7.35e-24: 100: 22.45
+	Hs
		516495 PABP1_HUMAN (6-202): 1.69e-41: 150: 18.27		PABP4_HUMAN (2-103): 9.14e-22: 96.7: 19.61
+	Hs
		516339 PABP1_HUMAN (6-202): 1.69e-41: 150: 18.27		PABP1_HUMAN (2-103): 1.99e-20: 92.9: 18.63
+	Hs
		516689 PABP1_HUMAN (6-202): 1.69e-41: 150: 18.27		PABP3_HUMAN (2-103): 2.88e-19: 89.4: 19.61
+	Xl
		1265032 ELAV2_XENLA (1-195): 1.22e-38: 138: 15.26		ELAV2_XENLA (10-92): 8.97e-24: 100: 25.00
+	Hs
		516471 PABP1_HUMAN (6-202): 1.69e-41: 150: 18.27		TIAR_HUMAN (8-102): 5.22e-19: 87.5: 26.32
+	Mm
		665745 PABP1_MOUSE (6-202): 2.07e-41: 150: 18.27		TIA1_MOUSE (12-196): 1.11e-17: 83.7: 11.89
+	Hs
		1020249 ELAV2_HUMAN (1-195): 6.01e-38: 136: 15.79		PABP4_HUMAN (2-103): 9.14e-22: 96.7: 19.61
+	Mm
		857332 SRSF2_MOUSE (1-221): 1.22e-43: 147: 100.00		TIA1_MOUSE (12-196): 1.11e-17: 83.7: 11.89
+	Dm
		1213164 Q9VAX3_DROME (14-102): 1.14e-27: 111: 30.34		Q8IMX4_DROME (13-96): 4.2e-15: 76.8: 18.82
+	Zm
		8143 A0A1D6ELH4_MAIZE (12-153): 1.15e-24: 103: 19.72		A0A1D6ELH4_MAIZE (12-99): 5.87e-17: 82.5: 20.46