HitPredict

Interactor 1: RUNX1 (Q01196)
Runt-related transcription factor 1 (Acute myeloid leukemia 1 protein) (Core-binding factor subunit alpha-2) (CBF-alpha-2) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEA2-alpha B) (PEBP2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit)
Gene: RUNX1

Interactor 2: TLE5 (Q08117)
TLE family member 5 (Amino-terminal enhancer of split) (Amino enhancer of split) (Gp130-associated protein GAM) (Grg-5) (Groucho-related protein 5) (Protein ESP1) (Protein GRG) (TLE family member 5, transcriptional modulator)
Gene: TLE5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	10825294
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 453 Hs			1 197
+	Hs
		964303 RUNX1_HUMAN (1-453): 0: 702: 100.00		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		964304 RUNX1_HUMAN (1-453): 0: 702: 100.00		TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50
+	Hs
		980600 RUNX3_HUMAN (1-453): 0: 540: 57.84		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		980602 RUNX2_HUMAN (43-453): 0: 522: 64.56		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Mm
		996430 RUNX2_MOUSE (43-453): 0: 539: 64.11		TLE1_MOUSE (2-197): 2.15e-101: 310: 63.00
+	Dm
		558358 RUNT_DROME (34-178): 2.37e-66: 222: 63.45		GROU_DROME (2-163): 3.54e-59: 198: 54.44
+	Ce
		107827 RUNX1_CAEEL (48-177): 1.01e-59: 199: 50.00		UNC37_CAEEL (18-160): 8.43e-43: 153: 28.47