HitPredict

Interactor 1: NC2B (Q01658)
Protein Dr1 (Down-regulator of transcription 1) (Negative cofactor 2-beta) (NC2-beta) (TATA-binding protein-associated phosphoprotein)
Gene: DR1

Interactor 2: NC2A (Q14919)
Dr1-associated corepressor (Dr1-associated protein 1) (Negative cofactor 2-alpha) (NC2-alpha)
Gene: DRAP1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 1.00 0.983

The method score is based on:

Property Details
Experiments 29997244, 26264872, 8608938, 33961781, 35235311, 37071682, 18838386, 26771498, 8972183, 15574413, unassigned1913, 31515488, 18692475, 32814053
Identification Methods fluorescent resonance energy transfer, affinity chromatography technology, cross-linking study, two hybrid, pull down, luminescence based mammalian interactome mapping, two hybrid array, two hybrid pooling approach, split luciferase complementation, protein complementation assay and 2 others

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Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains CBFD_NFYB_HMF~CBFD_NFYB_HMF
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0016251 - RNA polymerase II general transcription initiation factor activity
GO:0017025 - TBP-class protein binding
GO:0017054 - negative cofactor 2 complex
GO:0046982 - protein heterodimerization activity
and 1 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 176
Hs

1 205
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+ Dm

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Last updated: 15 Jul 2024