HitPredict

Interactor 1: EWS (Q01844)
RNA-binding protein EWS (EWS oncogene) (Ewing sarcoma breakpoint region 1 protein)
Gene: EWSR1

Interactor 2: EP300 (Q09472)
Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-)
Gene: EP300

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.677

Property	Details
Experiments	24999758, 33742100, 21988832, 18509338
Identification Methods	proximity labelling technology, affinity chromatography technology, two hybrid, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 656 Hs			1 2414
+	Hs
		998942 RBP56_HUMAN (109-555): 5.78e-53: 193: 35.05		EP300_HUMAN (1-2414): 0: 1113: 100.00
+	Hs
		318610 EYA4_HUMAN (3-271): 6.07e-39: 154: 18.02		EP300_HUMAN (1-2414): 0: 1113: 100.00
+	Hs
		726775 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		EP300_HUMAN (1-2414): 0: 1113: 100.00
+	Hs
		967540 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		NCOA3_HUMAN (1849-2386): 7.64e-52: 204: 21.89
+	Hs
		1271215 RBP56_HUMAN (109-555): 5.78e-53: 193: 35.05		TRI33_HUMAN (604-1201): 1.37e-44: 180: 14.50
+	Hs
		967517 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		TRI33_HUMAN (604-1201): 1.37e-44: 180: 14.50
+	Hs
		318764 EYA4_HUMAN (3-271): 6.07e-39: 154: 18.02		NCOA3_HUMAN (1849-2386): 7.64e-52: 204: 21.89
+	Hs
		518057 CO6A3_HUMAN (3-318): 2.21e-37: 152: 11.24		TRI33_HUMAN (604-1201): 1.37e-44: 180: 14.50
+	Hs
		967421 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		BRD8_HUMAN (965-1183): 9.91e-16: 86: 19.18
+	Hs
		967173 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		MDC1_HUMAN (455-1061): 8.69e-13: 76.6: 11.82
+	Hs
		967541 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		PCLO_HUMAN (533-1087): 8.45e-12: 73.6: 11.83
+	Hs
		967313 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		CBP_HUMAN (1752-2400): 4.44e-10: 67.9: 13.25
+	Hs
		318689 EYA4_HUMAN (3-271): 6.07e-39: 154: 18.02		CBP_HUMAN (1752-2400): 4.44e-10: 67.9: 13.25
+	Hs
		726817 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		MDC1_HUMAN (455-1061): 8.69e-13: 76.6: 11.82
+	Hs
		726907 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		PB1_HUMAN (1081-1145): 9.68e-11: 69.8: 36.92
+	Hs
		726964 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		CBP_HUMAN (1752-2400): 4.44e-10: 67.9: 13.25