HitPredict

Interactor 1: EWS (Q01844)
RNA-binding protein EWS (EWS oncogene) (Ewing sarcoma breakpoint region 1 protein)
Gene: EWSR1

Interactor 2: TADBP (Q13148)
TAR DNA-binding protein 43 (TDP-43)
Gene: TARDBP

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	29884807
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 656 Hs			1 414
+	Hs
		852117 RBP56_HUMAN (109-555): 5.78e-53: 193: 35.05		ROA3_HUMAN (98-269): 2.33e-69: 225: 28.57
+	Hs
		162015 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		HNRDL_HUMAN (62-376): 5.62e-71: 231: 23.60
+	Hs
		852019 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		ROA3_HUMAN (98-269): 2.33e-69: 225: 28.57
+	Hs
		726788 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		TADBP_HUMAN (1-414): 4.24e-84: 264: 100.00
+	Hs
		161976 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		HNRDL_HUMAN (62-376): 5.62e-71: 231: 23.60
+	Hs
		726672 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		ROA3_HUMAN (98-269): 2.33e-69: 225: 28.57
+	Dm
		1099594 CAZ_DROME (236-550): 2.31e-36: 142: 37.11		Q9W1I0_DROME (4-323): 2.53e-60: 200: 50.00
+	Hs
		1031411 RBP56_HUMAN (109-555): 5.78e-53: 193: 35.05		PABP4_HUMAN (98-274): 3.77e-37: 144: 19.02
+	Hs
		680441 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		TIA1_HUMAN (99-413): 2.4e-38: 144: 13.76
+	Hs
		516620 RBP56_HUMAN (109-555): 5.78e-53: 193: 35.05		PABP1_HUMAN (2-382): 7.78e-31: 126: 15.95
+	Mm
		857328 EWS_MOUSE (1-656): 4.67e-42: 163: 94.06		TIA1_MOUSE (99-413): 1.08e-36: 139: 12.92
+	Sc
		376785 HRB1_YEAST (241-452): 4.75e-35: 140: 21.76		PABP_YEAST (86-269): 2.74e-34: 136: 21.88
+	Hs
		726795 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		PABP4_HUMAN (98-274): 3.77e-37: 144: 19.02
+	Hs
		967165 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		HNRPD_HUMAN (81-238): 5.59e-21: 95.1: 35.93
+	Hs
		516383 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		PABP1_HUMAN (2-382): 7.78e-31: 126: 15.95
+	Hs
		726810 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		HNRPD_HUMAN (81-238): 5.59e-21: 95.1: 35.93
+	Sc
		376649 GBP2_YEAST (343-453): 3.82e-16: 83.2: 24.56		PABP_YEAST (86-269): 2.74e-34: 136: 21.88
+	Sc
		634002 GBP2_YEAST (343-453): 3.82e-16: 83.2: 24.56		HRP1_YEAST (101-289): 6.38e-20: 93.6: 31.50