HitPredict

Interactor 1: EWS (Q01844)
RNA-binding protein EWS (EWS oncogene) (Ewing sarcoma breakpoint region 1 protein)
Gene: EWSR1

Interactor 2: HNRPD (Q14103)
Heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) (AU-rich element RNA-binding protein 1)
Gene: HNRNPD

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	24999758, 26318153
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006355 - regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 656 Hs			1 355
+	Hs
		1271174 RBP56_HUMAN (109-555): 5.78e-53: 193: 35.05		ROAA_HUMAN (30-355): 3.41e-55: 185: 53.89
+	Hs
		162015 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		HNRDL_HUMAN (89-355): 3.71e-56: 190: 62.63
+	Hs
		852117 RBP56_HUMAN (109-555): 5.78e-53: 193: 35.05		ROA3_HUMAN (64-265): 2.66e-50: 174: 37.02
+	Hs
		967387 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		ROAA_HUMAN (30-355): 3.41e-55: 185: 53.89
+	Hs
		852019 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		ROA3_HUMAN (64-265): 2.66e-50: 174: 37.02
+	Hs
		1031411 RBP56_HUMAN (109-555): 5.78e-53: 193: 35.05		PABP4_HUMAN (88-272): 4.65e-43: 159: 18.52
+	Hs
		516620 RBP56_HUMAN (109-555): 5.78e-53: 193: 35.05		PABP1_HUMAN (88-272): 2.1e-42: 157: 16.93
+	Hs
		609978 RBP56_HUMAN (109-555): 5.78e-53: 193: 35.05		ROA2_HUMAN (98-277): 8.38e-39: 142: 41.40
+	Hs
		161976 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		HNRDL_HUMAN (89-355): 3.71e-56: 190: 62.63
+	Hs
		609816 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		ROA2_HUMAN (98-277): 8.38e-39: 142: 41.40
+	Hs
		726672 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		ROA3_HUMAN (64-265): 2.66e-50: 174: 37.02
+	Sc
		376785 HRB1_YEAST (241-452): 4.75e-35: 140: 21.76		PABP_YEAST (61-266): 4.09e-40: 150: 20.48
+	Hs
		516383 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		PABP1_HUMAN (88-272): 2.1e-42: 157: 16.93
+	Hs
		453508 RBP56_HUMAN (109-555): 5.78e-53: 193: 35.05		ROA1_HUMAN (63-177): 4.79e-20: 92: 26.83
+	Hs
		609735 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		ROA2_HUMAN (98-277): 8.38e-39: 142: 41.40
+	Hs
		453296 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		ROA1_HUMAN (63-177): 4.79e-20: 92: 26.83
+	Hs
		680441 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		TIA1_HUMAN (176-270): 9.56e-14: 73.6: 18.75
+	Mm
		857328 EWS_MOUSE (1-656): 4.67e-42: 163: 94.06		TIA1_MOUSE (176-270): 8.88e-14: 73.6: 18.75
+	Hs
		318604 EYA4_HUMAN (3-271): 6.07e-39: 154: 18.02		TIAR_HUMAN (174-269): 2.98e-13: 72.1: 16.50
+	Hs
		453189 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		ROA1_HUMAN (63-177): 4.79e-20: 92: 26.83