HitPredict

Interactor 1: EWS (Q01844)
RNA-binding protein EWS (EWS oncogene) (Ewing sarcoma breakpoint region 1 protein)
Gene: EWSR1

Interactor 2: LARP7 (Q4G0J3)
La-related protein 7 (La ribonucleoprotein domain family member 7) (hLARP7) (P-TEFb-interaction protein for 7SK stability) (PIP7S)
Gene: LARP7

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	29845934
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	La~RRM_1, RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 656 Hs			1 582
+	Hs
		1116429 RBP56_HUMAN (109-555): 5.78e-53: 193: 35.05		LARP7_HUMAN (1-582): 1.26e-127: 388: 100.00
+	Hs
		726864 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		LARP7_HUMAN (1-582): 1.26e-127: 388: 100.00
+	Hs
		212147 HTSF1_HUMAN (310-448): 3.35e-28: 122: 20.55		LARP7_HUMAN (1-582): 1.26e-127: 388: 100.00
+	Hs
		1031411 RBP56_HUMAN (109-555): 5.78e-53: 193: 35.05		PABP4_HUMAN (1-208): 8.15e-41: 158: 11.98
+	Hs
		516620 RBP56_HUMAN (109-555): 5.78e-53: 193: 35.05		PABP1_HUMAN (1-405): 1.94e-40: 157: 10.29
+	Hs
		403193 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		LA_HUMAN (24-365): 5.96e-44: 163: 18.83
+	Hs
		726795 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		PABP4_HUMAN (1-208): 8.15e-41: 158: 11.98
+	Hs
		516383 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		PABP1_HUMAN (1-405): 1.94e-40: 157: 10.29
+	Sc
		376785 HRB1_YEAST (241-452): 4.75e-35: 140: 21.76		PABP_YEAST (9-243): 8.44e-33: 134: 13.47
+	Mm
		857328 EWS_MOUSE (1-656): 4.67e-42: 163: 94.06		TIA1_MOUSE (120-325): 5.06e-24: 106: 13.94
+	Hs
		1162631 RBP56_HUMAN (109-555): 5.78e-53: 193: 35.05		LARP1_HUMAN (29-114): 6.35e-13: 73.8: 40.23
+	Hs
		1077435 RBP56_HUMAN (109-555): 5.78e-53: 193: 35.05		ELAV1_HUMAN (92-211): 7.72e-13: 71.9: 22.50
+	Hs
		967202 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		ELAV1_HUMAN (92-211): 7.72e-13: 71.9: 22.50
+	Sc
		376649 GBP2_YEAST (343-453): 3.82e-16: 83.2: 24.56		PABP_YEAST (9-243): 8.44e-33: 134: 13.47
+	Hs
		726889 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		LARP1_HUMAN (29-114): 6.35e-13: 73.8: 40.23
+	Hs
		726846 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		ELAV1_HUMAN (92-211): 7.72e-13: 71.9: 22.50