HitPredict

Interactor 1: EWS (Q01844)
RNA-binding protein EWS (EWS oncogene) (Ewing sarcoma breakpoint region 1 protein)
Gene: EWSR1

Interactor 2: PABP2 (Q86U42)
Polyadenylate-binding protein 2 (PABP-2) (Poly(A)-binding protein 2) (Nuclear poly(A)-binding protein 1) (Poly(A)-binding protein II) (PABII) (Polyadenylate-binding nuclear protein 1)
Gene: PABPN1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	24999758
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 656 Hs			1 306
+	Mm
		892749 Q8BQ46_MOUSE (109-555): 4.7e-53: 193: 35.35		CIRBP_MOUSE (167-302): 1.7e-32: 119: 18.90
+	Hs
		516620 RBP56_HUMAN (109-555): 5.78e-53: 193: 35.05		PABP1_HUMAN (59-260): 3.2e-22: 98.8: 11.33
+	Hs
		1031411 RBP56_HUMAN (109-555): 5.78e-53: 193: 35.05		PABP4_HUMAN (163-260): 1.04e-20: 94.2: 17.17
+	Hs
		726905 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		PABP2_HUMAN (96-306): 9.35e-43: 150: 100.00
+	Hs
		967344 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		DAZP1_HUMAN (163-285): 3.6e-21: 94.6: 21.14
+	Hs
		680441 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		TIA1_HUMAN (167-278): 4.88e-19: 88.4: 15.93
+	Hs
		726675 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		NCBP2_HUMAN (142-298): 5.3e-33: 120: 15.82
+	Hs
		318693 EYA4_HUMAN (3-271): 6.07e-39: 154: 18.02		DAZP1_HUMAN (163-285): 3.6e-21: 94.6: 21.14
+	Hs
		212116 HTSF1_HUMAN (310-448): 3.35e-28: 122: 20.55		NCBP2_HUMAN (142-298): 5.3e-33: 120: 15.82
+	Hs
		516383 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		PABP1_HUMAN (59-260): 3.2e-22: 98.8: 11.33
+	Sc
		376785 HRB1_YEAST (241-452): 4.75e-35: 140: 21.76		PABP_YEAST (143-260): 3.27e-19: 89.6: 20.17
+	Hs
		726795 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		PABP4_HUMAN (163-260): 1.04e-20: 94.2: 17.17
+	Sc
		694039 HRB1_YEAST (241-452): 4.75e-35: 140: 21.76		PUB1_YEAST (165-255): 5.29e-09: 58.8: 18.48
+	Sc
		376649 GBP2_YEAST (343-453): 3.82e-16: 83.2: 24.56		PABP_YEAST (143-260): 3.27e-19: 89.6: 20.17
+	Sc
		633946 GBP2_YEAST (343-453): 3.82e-16: 83.2: 24.56		HRB1_YEAST (153-268): 1.5e-16: 81.4: 29.51
+	Sc
		633929 GBP2_YEAST (343-453): 3.82e-16: 83.2: 24.56		PUB1_YEAST (165-255): 5.29e-09: 58.8: 18.48