HitPredict

Interactor 1: EWS (Q01844)
RNA-binding protein EWS (EWS oncogene) (Ewing sarcoma breakpoint region 1 protein)
Gene: EWSR1

Interactor 2: RBM45 (Q8IUH3)
RNA-binding protein 45 (Developmentally-regulated RNA-binding protein 1) (RB-1) (RNA-binding motif protein 45)
Gene: RBM45

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	29884807
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 656 Hs			1 476
+	Hs
		642763 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		ELAV4_HUMAN (3-329): 3.11e-82: 261: 23.72
+	Hs
		967171 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		ELAV3_HUMAN (7-328): 1.72e-82: 261: 22.84
+	Hs
		1031411 RBP56_HUMAN (109-555): 5.78e-53: 193: 35.05		PABP4_HUMAN (5-411): 7.51e-60: 209: 14.73
+	Hs
		726913 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		RBM45_HUMAN (1-476): 1.33e-78: 254: 98.53
+	Hs
		726795 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		PABP4_HUMAN (5-411): 7.51e-60: 209: 14.73
+	Sc
		376785 HRB1_YEAST (241-452): 4.75e-35: 140: 21.76		PABP_YEAST (5-285): 1.65e-37: 146: 15.83
+	Hs
		1271149 RBP56_HUMAN (109-555): 5.78e-53: 193: 35.05		CELF1_HUMAN (126-204): 1.68e-14: 77.5: 23.75
+	Hs
		516620 RBP56_HUMAN (109-555): 5.78e-53: 193: 35.05		PABP1_HUMAN (382-470): 6.62e-13: 72.7: 11.58
+	Hs
		1077435 RBP56_HUMAN (109-555): 5.78e-53: 193: 35.05		ELAV1_HUMAN (5-108): 8.6e-12: 68.2: 24.04
+	Hs
		967317 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		CELF1_HUMAN (126-204): 1.68e-14: 77.5: 23.75
+	Hs
		967500 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		PUF60_HUMAN (38-180): 7.95e-12: 69.3: 28.28
+	Hs
		967202 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		ELAV1_HUMAN (5-108): 8.6e-12: 68.2: 24.04
+	Sc
		376649 GBP2_YEAST (343-453): 3.82e-16: 83.2: 24.56		PABP_YEAST (5-285): 1.65e-37: 146: 15.83
+	Hs
		726969 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		CELF1_HUMAN (126-204): 1.68e-14: 77.5: 23.75
+	Hs
		516383 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		PABP1_HUMAN (382-470): 6.62e-13: 72.7: 11.58
+	Hs
		726846 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		ELAV1_HUMAN (5-108): 8.6e-12: 68.2: 24.04