HitPredict

Interactor 1: EWS (Q01844)
RNA-binding protein EWS (EWS oncogene) (Ewing sarcoma breakpoint region 1 protein)
Gene: EWSR1

Interactor 2: SOX21 (Q9Y651)
Transcription factor SOX-21 (SOX-A)
Gene: SOX21

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0006355 - regulation of DNA-templated transcription
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 656 Hs			1 276
+	Hs
		818317 RBP56_HUMAN (109-555): 5.78e-53: 193: 35.05		SOX2_HUMAN (2-269): 8.35e-43: 150: 37.41
+	Hs
		817937 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		SOX2_HUMAN (2-269): 8.35e-43: 150: 37.41
+	Hs
		996807 RBP56_HUMAN (109-555): 5.78e-53: 193: 35.05		SSRP1_HUMAN (3-168): 3.19e-31: 123: 18.07
+	Hs
		967374 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		CIC_HUMAN (3-228): 2.75e-35: 136: 24.78
+	Hs
		967456 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		TF7L2_HUMAN (11-274): 8.95e-32: 125: 17.80
+	Mm
		818695 EYA1_MOUSE (3-277): 2.57e-40: 157: 22.50		SOX2_MOUSE (2-269): 2.03e-41: 146: 37.41
+	Hs
		518050 CO6A3_HUMAN (3-318): 2.21e-37: 152: 11.24		SOX2_HUMAN (2-269): 8.35e-43: 150: 37.41
+	Hs
		727730 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		SOX5_HUMAN (3-166): 7.68e-31: 123: 29.88
+	Hs
		967399 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		SOX7_HUMAN (4-269): 1.43e-29: 116: 29.09
+	Hs
		318703 EYA4_HUMAN (3-271): 6.07e-39: 154: 18.02		CIC_HUMAN (3-228): 2.75e-35: 136: 24.78
+	Hs
		726648 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		SOX2_HUMAN (2-269): 8.35e-43: 150: 37.41
+	Hs
		225698 EYA4_HUMAN (3-271): 6.07e-39: 154: 18.02		SOX15_HUMAN (2-208): 3.95e-34: 125: 39.61
+	Hs
		175773 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		HMGB3_HUMAN (12-169): 3.62e-22: 92.8: 19.38
+	Hs
		567679 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		UBF1_HUMAN (5-187): 1.39e-17: 84.3: 15.51
+	Hs
		727047 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		TF7L2_HUMAN (11-274): 8.95e-32: 125: 17.80
+	Hs
		517905 COBA1_HUMAN (2-522): 4.54e-20: 97.6: 11.51		SOX2_HUMAN (2-269): 8.35e-43: 150: 37.41
+	Hs
		118599 EYA2_HUMAN (27-278): 1.48e-18: 91.3: 20.16		CIC_HUMAN (3-228): 2.75e-35: 136: 24.78