HitPredict

Interactor 1: OCRL (Q01968)
Inositol polyphosphate 5-phosphatase OCRL (EC 3.1.3.36) (EC 3.1.3.56) (Inositol polyphosphate 5-phosphatase OCRL-1) (OCRL-1) (Lowe oculocerebrorenal syndrome protein) (Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase) (EC 3.1.3.86)
Gene: OCRL

Interactor 2: RAB31 (Q13636)
Ras-related protein Rab-31 (Ras-related protein Rab-22B)
Gene: RAB31

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	1.00	0.821

Property	Details
Experiments	19795375, 21378754
Identification Methods	two hybrid, affinity chromatography technology, pull down, fluorescence polarization spectroscopy
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Ras~RhoGAP
Common GO terms	GO:0005769 - early endosome GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0031901 - early endosome membrane
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 901 Hs			1 195
+	Hs
		592207 OCRL_HUMAN (1-901): 0: 1075: 100.00		RAB5A_HUMAN (4-195): 4.32e-93: 271: 45.92
+	Hs
		844489 OCRL_HUMAN (1-901): 0: 1075: 100.00		RAB5C_HUMAN (4-195): 2.12e-92: 270: 45.92
+	Hs
		895348 OCRL_HUMAN (1-901): 0: 1075: 100.00		RAB5B_HUMAN (2-195): 2.32e-91: 267: 44.44
+	Hs
		918850 OCRL_HUMAN (1-901): 0: 1075: 100.00		RAB1A_HUMAN (7-195): 5.95e-87: 256: 38.14
+	Hs
		968218 OCRL_HUMAN (1-901): 0: 1075: 100.00		RAB1B_HUMAN (7-195): 3.69e-86: 253: 36.79
+	Hs
		968196 OCRL_HUMAN (1-901): 0: 1075: 100.00		RAB1C_HUMAN (7-195): 1.29e-83: 247: 37.31
+	Hs
		914016 OCRL_HUMAN (1-901): 0: 1075: 100.00		RB11A_HUMAN (7-195): 7.42e-82: 243: 35.15
+	Rn
		112176 R9PXS2_RAT (14-901): 0: 1038: 93.81		RAB5A_RAT (4-195): 4.67e-93: 271: 45.92
+	Rn
		1157320 R9PXS2_RAT (14-901): 0: 1038: 93.81		RAB1A_RAT (7-195): 5.95e-87: 256: 38.14
+	Hs
		884472 OCRL_HUMAN (1-901): 0: 1075: 100.00		RAB25_HUMAN (7-167): 5.51e-46: 152: 41.62
+	Hs
		592125 I5P2_HUMAN (143-897): 0: 719: 50.27		RAB5A_HUMAN (4-195): 4.32e-93: 271: 45.92
+	Dm
		185463 O46094_DROME (209-900): 1.12e-177: 537: 33.15		O18332_DROME (7-195): 2.54e-85: 251: 36.08
+	Dm
		220979 O46094_DROME (209-900): 1.12e-177: 537: 33.15		RAB5_DROME (6-195): 3.18e-61: 191: 48.42
+	Dm
		185584 O46094_DROME (209-900): 1.12e-177: 537: 33.15		RAB6_DROME (4-175): 5.85e-46: 152: 38.95
+	Dm
		185619 Q95R90_DROME (380-900): 5.7e-116: 365: 32.27		RAB6_DROME (4-175): 5.85e-46: 152: 38.95