HitPredict - High confidence protein-protein interactions

Interactor 1: MEF2A (Q02078)
Myocyte-specific enhancer factor 2A (Serum response factor-like protein 1)
Gene: MEF2A

Interactor 2: MEF2C (Q06413)
Myocyte-specific enhancer factor 2C (Myocyte enhancer factor 2C)
Gene: MEF2C

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	25609649, 33961781
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SRF-TF~SRF-TF
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000165 - MAPK cascade GO:0000785 - chromatin GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding and 17 others more... GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific GO:0003700 - DNA-binding transcription factor activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0006915 - apoptotic process GO:0007507 - heart development GO:0007517 - muscle organ development GO:0010628 - positive regulation of gene expression GO:0030154 - cell differentiation GO:0042826 - histone deacetylase binding GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0046982 - protein heterodimerization activity GO:0061629 - RNA polymerase II-specific DNA-binding transcription factor binding GO:0071277 - cellular response to calcium ion GO:0140297 - DNA-binding transcription factor binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1	507
Hs

1	473

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Last updated: 15 Jul 2024