HitPredict

Interactor 1: MEF2B (Q02080)
Myocyte-specific enhancer factor 2B (RSRFR2) (Serum response factor-like protein 2)
Gene: MEF2B

Interactor 2: HDAC9 (Q9UKV0)
Histone deacetylase 9 (HD9) (EC 3.5.1.98) (Histone deacetylase 7B) (HD7) (HD7b) (Histone deacetylase-related protein) (MEF2-interacting transcription repressor MITR)
Gene: HDAC9

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	15567413
Identification Methods	x-ray crystallography
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005667 - transcription regulator complex GO:0007507 - heart development GO:0042826 - histone deacetylase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 365 Hs			1 1011
+	Hs
		968804 MEF2A_HUMAN (1-352): 9.13e-63: 210: 33.06		HDAC9_HUMAN (1-1011): 0: 799: 100.00
+	Hs
		987233 MEF2C_HUMAN (1-290): 1.03e-60: 204: 38.10		HDAC9_HUMAN (1-1011): 0: 799: 100.00
+	Hs
		880687 MEF2B_HUMAN (1-365): 3.46e-98: 297: 100.00		HDAC4_HUMAN (1-1009): 0: 691: 54.67
+	Hs
		880686 MEF2A_HUMAN (1-352): 9.13e-63: 210: 33.06		HDAC4_HUMAN (1-1009): 0: 691: 54.67
+	Hs
		880693 MEF2C_HUMAN (1-290): 1.03e-60: 204: 38.10		HDAC4_HUMAN (1-1009): 0: 691: 54.67
+	Mm
		1157743 MEF2C_MOUSE (1-290): 3.61e-61: 205: 37.76		HDAC4_MOUSE (1-1009): 0: 684: 53.86
+	Hs
		880729 MEF2D_HUMAN (1-352): 4.09e-58: 198: 33.24		HDAC4_HUMAN (1-1009): 0: 691: 54.67
+	Mm
		1141851 MEF2A_MOUSE (1-352): 7.09e-60: 202: 33.43		HDAC4_MOUSE (1-1009): 0: 684: 53.86
+	Hs
		968805 MEF2A_HUMAN (1-352): 9.13e-63: 210: 33.06		HDAC5_HUMAN (1-1008): 0: 612: 55.67
+	Hs
		987234 MEF2C_HUMAN (1-290): 1.03e-60: 204: 38.10		HDAC5_HUMAN (1-1008): 0: 612: 55.67
+	Mm
		1112770 MEF2C_MOUSE (1-290): 3.61e-61: 205: 37.76		Q3UJF1_MOUSE (1-1008): 0: 609: 54.42
+	Mm
		1112756 MEF2A_MOUSE (1-352): 7.09e-60: 202: 33.43		Q3UJF1_MOUSE (1-1008): 0: 609: 54.42
+	Hs
		968793 MEF2A_HUMAN (1-352): 9.13e-63: 210: 33.06		HDAC7_HUMAN (75-1008): 1.75e-170: 525: 41.57
+	Hs
		987223 MEF2C_HUMAN (1-290): 1.03e-60: 204: 38.10		HDAC7_HUMAN (75-1008): 1.75e-170: 525: 41.57
+	Mm
		1207907 MEF2C_MOUSE (1-290): 3.61e-61: 205: 37.76		HDAC7_MOUSE (71-1008): 2.68e-155: 485: 41.45
+	Mm
		1141852 MEF2A_MOUSE (1-352): 7.09e-60: 202: 33.43		HDAC7_MOUSE (71-1008): 2.68e-155: 485: 41.45
+	Hs
		968816 MEF2B_HUMAN (1-365): 3.46e-98: 297: 100.00		HDAC6_HUMAN (564-1009): 2e-107: 363: 30.95
+	Hs
		968777 MEF2A_HUMAN (1-352): 9.13e-63: 210: 33.06		HDAC1_HUMAN (623-1009): 3.2e-140: 430: 23.49
+	Hs
		177265 MEF2A_HUMAN (1-352): 9.13e-63: 210: 33.06		HDAC3_HUMAN (631-1007): 9.3e-131: 404: 22.34
+	Hs
		177297 MEF2D_HUMAN (1-352): 4.09e-58: 198: 33.24		HDAC3_HUMAN (631-1007): 9.3e-131: 404: 22.34