HitPredict

Interactor 1: UBC7 (Q02159)
Ubiquitin-conjugating enzyme E2 7 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme 7) (Ubiquitin carrier protein) (Ubiquitin-conjugating enzyme E2-18 kDa) (Ubiquitin-protein ligase)
Gene: UBC7

Interactor 2: HRD1 (Q08109)
ERAD-associated E3 ubiquitin-protein ligase HRD1 (EC 2.3.2.27) (HMG-CoA reductase degradation protein 1) (RING-type E3 ubiquitin transferase HRD1)
Gene: HRD1

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.986

The method score is based on:

Property Details
Experiments 11139575, 14593114, 16270032, 25646477, 27321670, 27170191, 27264873, 32094691, 33015833, 37066402, 11146622, 19394298, 23665229, 18321851, 19324879, 19366730
Identification Methods affinity chromatography technology, enzymatic study, pull down
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains UQ_con~zf-RING_2
Common GO terms GO:0000839 - Hrd1p ubiquitin ligase ERAD-L complex
GO:0004842 - ubiquitin-protein transferase activity
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0006511 - ubiquitin-dependent protein catabolic process
and 2 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Last updated: 15 Jul 2024