HitPredict

Interactor 1: RSC4 (Q02206)
Chromatin structure-remodeling complex subunit RSC4 (RSC complex subunit RSC4) (Remodel the structure of chromatin complex subunit 4)
Gene: RSC4

Interactor 2: GCN5 (Q03330)
Histone acetyltransferase GCN5 (EC 2.3.1.48) (Histone crotonyltransferase GCN5) (EC 2.3.1.-)
Gene: GCN5

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.818

Property	Details
Experiments	17803945, 21673141, 21179020
Identification Methods	x-ray crystallography, enzymatic study, tandem affinity purification
Interaction Type	association, direct interaction

Property	Details
Interacting Pfam domains	Bromodomain~Bromodomain
Common GO terms	GO:0006338 - chromatin remodeling GO:0070577 - lysine-acetylated histone binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 625 Sc			1 439
+	Sc
		728741 RSC4_YEAST (1-625): 0: 597: 100.00		BDF1_YEAST (349-432): 9.45e-09: 59.7: 38.37
+	Mm
		101467 F8VPR5_MOUSE (2-154): 3.85e-23: 107: 17.90		KAT2B_MOUSE (1-430): 0: 535: 39.59
+	Mm
		101468 F8VPR5_MOUSE (2-154): 3.85e-23: 107: 17.90		KAT2A_MOUSE (14-430): 1.8e-168: 495: 37.97
+	Hs
		164439 PHIP_HUMAN (16-470): 3.23e-64: 232: 15.67		TRI66_HUMAN (232-435): 1.04e-41: 160: 19.52
+	Hs
		1262811 PHIP_HUMAN (16-470): 3.23e-64: 232: 15.67		CECR2_HUMAN (263-439): 4.66e-38: 149: 30.34
+	Hs
		1067068 PHIP_HUMAN (16-470): 3.23e-64: 232: 15.67		BRD3_HUMAN (303-435): 2.85e-36: 143: 30.44
+	Hs
		244704 PHIP_HUMAN (16-470): 3.23e-64: 232: 15.67		BRD4_HUMAN (256-438): 5.45e-36: 143: 25.53
+	Hs
		631525 PHIP_HUMAN (16-470): 3.23e-64: 232: 15.67		BRD2_HUMAN (279-436): 2.56e-34: 137: 26.25
+	Hs
		1199218 PB1_HUMAN (24-312): 2.23e-43: 169: 18.37		TRI33_HUMAN (225-439): 1.05e-41: 160: 20.65
+	Sp
		1336893 YK82_SCHPO (36-401): 1.54e-52: 194: 12.50		BDF1_SCHPO (280-438): 4.46e-34: 135: 24.22
+	Hs
		1199169 PHIP_HUMAN (16-470): 3.23e-64: 232: 15.67		PB1_HUMAN (289-437): 7.01e-17: 85.5: 15.48
+	Hs
		1067030 PB1_HUMAN (24-312): 2.23e-43: 169: 18.37		BRD3_HUMAN (303-435): 2.85e-36: 143: 30.44
+	Hs
		244619 PB1_HUMAN (24-312): 2.23e-43: 169: 18.37		BRD4_HUMAN (256-438): 5.45e-36: 143: 25.53
+	Hs
		319248 PB1_HUMAN (24-312): 2.23e-43: 169: 18.37		BRD1_HUMAN (319-422): 9.27e-36: 142: 36.54
+	Hs
		631488 PB1_HUMAN (24-312): 2.23e-43: 169: 18.37		BRD2_HUMAN (279-436): 2.56e-34: 137: 26.25
+	Hs
		1164185 BRWD3_HUMAN (32-468): 6.52e-58: 213: 16.33		BRWD1_HUMAN (276-430): 1.63e-13: 75.1: 16.77
+	Mm
		101463 F8VPR5_MOUSE (2-154): 3.85e-23: 107: 17.90		TRI33_MOUSE (225-439): 1.79e-42: 162: 21.05
+	Zm
		44100 A0A1D6PWP4_MAIZE (8-199): 6.58e-25: 111: 16.16		A0A1D6PWP4_MAIZE (295-434): 2.21e-37: 146: 28.17
+	Mm
		70879 F8VPR5_MOUSE (2-154): 3.85e-23: 107: 17.90		EP300_MOUSE (257-431): 4.09e-38: 149: 23.08
+	Dm
		631317 BRM_DROME (166-291): 1.07e-32: 137: 29.37		Q9VC36_DROME (335-432): 6.07e-15: 79.3: 39.00