HitPredict

Interactor 1: PDCD1 (Q02242)
Programmed cell death protein 1 (Protein PD-1) (mPD-1) (CD antigen CD279)
Gene: PDCD1

Interactor 2: PD1L2 (Q9WUL5)
Programmed cell death 1 ligand 2 (PD-1 ligand 2) (PD-L2) (PDCD1 ligand 2) (Programmed death ligand 2) (Butyrophilin B7-DC) (B7-DC) (CD antigen CD273)
Gene: Pdcd1lg2

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	18641123, 12719480
Identification Methods	x-ray crystallography, surface plasmon resonance
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	C2-set_2~V-set
Common GO terms	GO:0002250 - adaptive immune response GO:0009897 - external side of plasma membrane
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 288 Mm			1 247
+	Mm
		970112 PDCD1_MOUSE (1-288): 0: 517: 100.00		PD1L1_MOUSE (21-247): 2.4e-58: 188: 33.74
+	Hs
		1067951 PDCD1_HUMAN (1-288): 2e-154: 434: 56.90		PD1L1_HUMAN (21-246): 1.4e-58: 189: 36.29
+	Hs
		1067939 PDCD1_HUMAN (1-288): 2e-154: 434: 56.90		PD1L2_HUMAN (15-247): 2.57e-52: 172: 70.39