HitPredict

Interactor 1: SOS2 (Q02384)
Son of sevenless homolog 2 (SOS-2) (mSOS-2)
Gene: SOS2

Interactor 2: GRB2 (Q60631)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.812

Property	Details
Experiments	15953601, 15102471, 23452850
Identification Methods	anti bait coimmunoprecipitation, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PH~SH3_1, RhoGEF~SH3_1
Common GO terms	GO:0005886 - plasma membrane GO:0007265 - Ras protein signal transduction GO:0008286 - insulin receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1333 Mm			1 217
+	Hs
		924512 SOS2_HUMAN (1-1333): 0: 946: 94.97		GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54
+	Hs
		924511 SOS1_HUMAN (1-1331): 0: 891: 66.81		GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54
+	Mm
		1141134 SOS1_MOUSE (1-1331): 0: 874: 66.57		GRB2_MOUSE (1-217): 3.97e-74: 225: 100.00
+	Hs
		557669 SOS2_HUMAN (1-1333): 0: 946: 94.97		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		337447 SOS2_HUMAN (1-1333): 0: 946: 94.97		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		411690 SOS1_HUMAN (1-1331): 0: 891: 66.81		LCK_HUMAN (3-202): 7.66e-38: 138: 28.91
+	Hs
		992521 SOS2_HUMAN (1-1333): 0: 946: 94.97		ITSN2_HUMAN (2-61): 3.57e-15: 75.7: 36.67
+	Hs
		412151 SOS2_HUMAN (1-1333): 0: 946: 94.97		FYN_HUMAN (161-215): 4.88e-13: 69.2: 31.58
+	Hs
		992508 SOS2_HUMAN (1-1333): 0: 946: 94.97		ITSN1_HUMAN (160-216): 3.02e-11: 64.2: 33.33
+	Hs
		275188 SOS2_HUMAN (1-1333): 0: 946: 94.97		GRAP2_HUMAN (3-55): 7.92e-11: 62.5: 39.62
+	Hs
		522935 SOS2_HUMAN (1-1333): 0: 946: 94.97		SRC_HUMAN (160-215): 1.74e-10: 61.9: 31.03
+	Hs
		557668 SOS1_HUMAN (1-1331): 0: 891: 66.81		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		337446 SOS1_HUMAN (1-1331): 0: 891: 66.81		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		992496 SOS1_HUMAN (1-1331): 0: 891: 66.81		ITSN2_HUMAN (2-61): 3.57e-15: 75.7: 36.67
+	Hs
		412150 SOS1_HUMAN (1-1331): 0: 891: 66.81		FYN_HUMAN (161-215): 4.88e-13: 69.2: 31.58
+	Hs
		992475 SOS1_HUMAN (1-1331): 0: 891: 66.81		GRAP_HUMAN (3-57): 2.36e-13: 68: 36.36
+	Hs
		442816 SOS1_HUMAN (1-1331): 0: 891: 66.81		HCK_HUMAN (116-215): 1.24e-11: 64.9: 19.61
+	Hs
		992477 SOS1_HUMAN (1-1331): 0: 891: 66.81		ITSN1_HUMAN (160-216): 3.02e-11: 64.2: 33.33
+	Hs
		522934 SOS1_HUMAN (1-1331): 0: 891: 66.81		SRC_HUMAN (160-215): 1.74e-10: 61.9: 31.03
+	Dm
		644366 SOS_DROME (8-1320): 0: 693: 41.85		GRAP_DROME (1-215): 5.25e-62: 193: 61.86