HitPredict

Interactor 1: DSC2 (Q02487)
Desmocollin-2 (Cadherin family member 2) (Desmocollin-3) (Desmosomal glycoprotein II) (Desmosomal glycoprotein III)
Gene: DSC2

Interactor 2: NTRK2 (Q16620)
BDNF/NT-3 growth factors receptor (EC 2.7.10.1) (GP145-TrkB) (Trk-B) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Tropomyosin-related kinase B)
Gene: NTRK2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 901 Hs			1 822
+	Hs
		384675 DSC2_HUMAN (1-901): 0: 855: 100.00		NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85
+	Hs
		1055826 DSC3_HUMAN (1-901): 0: 806: 66.70		NTRK3_HUMAN (13-822): 1.98e-178: 536: 52.84
+	Hs
		508000 DSC3_HUMAN (1-901): 0: 806: 66.70		FGFR1_HUMAN (180-821): 3.75e-164: 498: 23.77
+	Hs
		665215 DSC2_HUMAN (1-901): 0: 855: 100.00		EPHA2_HUMAN (148-822): 4.29e-141: 443: 22.43
+	Hs
		507817 CADH1_HUMAN (28-897): 0: 714: 28.09		FGFR1_HUMAN (180-821): 3.75e-164: 498: 23.77
+	Hs
		521744 CADH1_HUMAN (28-897): 0: 714: 28.09		EPHA2_HUMAN (148-822): 4.29e-141: 443: 22.43
+	Hs
		666577 DSC2_HUMAN (1-901): 0: 855: 100.00		LTK_HUMAN (506-808): 6.29e-61: 223: 38.07
+	Hs
		1055828 DSC3_HUMAN (1-901): 0: 806: 66.70		DDR2_HUMAN (491-807): 5.97e-75: 263: 43.40
+	Hs
		435643 DSC3_HUMAN (1-901): 0: 806: 66.70		IGF1R_HUMAN (513-797): 1.01e-70: 256: 43.95
+	Hs
		411386 DSC3_HUMAN (1-901): 0: 806: 66.70		INSR_HUMAN (513-809): 2.11e-70: 254: 43.38
+	Hs
		537741 DSC3_HUMAN (1-901): 0: 806: 66.70		INSRR_HUMAN (513-814): 4.91e-68: 247: 42.43
+	Hs
		521890 CADH1_HUMAN (28-897): 0: 714: 28.09		DDR1_HUMAN (535-807): 1.28e-74: 263: 47.37
+	Hs
		521969 CADH1_HUMAN (28-897): 0: 714: 28.09		DDR2_HUMAN (491-807): 5.97e-75: 263: 43.40
+	Hs
		435534 CADH3_HUMAN (7-897): 0: 635: 27.50		IGF1R_HUMAN (513-797): 1.01e-70: 256: 43.95
+	Hs
		384674 DSG1_HUMAN (130-573): 2.65e-65: 239: 33.18		NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85
+	Hs
		384238 CADH2_HUMAN (4-385): 1.04e-51: 197: 15.55		NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85
+	Hs
		434321 PCDGH_HUMAN (1-464): 7.02e-94: 318: 16.74		RET_HUMAN (436-820): 1.09e-115: 379: 33.00
+	Hs
		507842 CADH2_HUMAN (4-385): 1.04e-51: 197: 15.55		FGFR1_HUMAN (180-821): 3.75e-164: 498: 23.77
+	Hs
		434134 CADH2_HUMAN (4-385): 1.04e-51: 197: 15.55		RET_HUMAN (436-820): 1.09e-115: 379: 33.00
+	Hs
		435531 CADH2_HUMAN (4-385): 1.04e-51: 197: 15.55		IGF1R_HUMAN (513-797): 1.01e-70: 256: 43.95