HitPredict

Interactor 1: PAX5 (Q02548)
Paired box protein Pax-5 (B-cell-specific transcription factor) (BSAP)
Gene: PAX5

Interactor 2: TLE4 (Q04727)
Transducin-like enhancer protein 4 (Grg-4) (Groucho-related protein 4)
Gene: TLE4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	0.60	0.636

Property	Details
Experiments	10811620, 12153506
Identification Methods	two hybrid, pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 391 Hs			1 773
+	Hs
		641379 PAX6_HUMAN (13-391): 8.28e-85: 265: 34.21		TLE4_HUMAN (1-773): 0: 622: 100.00
+	Hs
		620144 PAX7_HUMAN (7-387): 4.72e-83: 264: 34.65		TLE4_HUMAN (1-773): 0: 622: 100.00
+	Mm
		623700 PAX3_MOUSE (7-380): 1.64e-80: 256: 34.62		TLE4_MOUSE (1-773): 0: 623: 99.61
+	Hs
		973842 PAX2_HUMAN (1-391): 9.44e-97: 296: 62.20		TLE1_HUMAN (8-773): 0: 580: 86.27
+	Hs
		641377 PAX6_HUMAN (13-391): 8.28e-85: 265: 34.21		TLE1_HUMAN (8-773): 0: 580: 86.27
+	Hs
		620142 PAX7_HUMAN (7-387): 4.72e-83: 264: 34.65		TLE1_HUMAN (8-773): 0: 580: 86.27
+	Hs
		980927 PAX8_HUMAN (12-389): 2.17e-67: 221: 49.00		TLE4_HUMAN (1-773): 0: 622: 100.00
+	Hs
		973843 PAX2_HUMAN (1-391): 9.44e-97: 296: 62.20		TLE3_HUMAN (8-773): 0: 539: 80.90
+	Hs
		641378 PAX6_HUMAN (13-391): 8.28e-85: 265: 34.21		TLE3_HUMAN (8-773): 0: 539: 80.90
+	Hs
		620143 PAX7_HUMAN (7-387): 4.72e-83: 264: 34.65		TLE3_HUMAN (8-773): 0: 539: 80.90
+	Hs
		980588 PAX8_HUMAN (12-389): 2.17e-67: 221: 49.00		TLE1_HUMAN (8-773): 0: 580: 86.27
+	Hs
		980733 PAX8_HUMAN (12-389): 2.17e-67: 221: 49.00		TLE3_HUMAN (8-773): 0: 539: 80.90
+	Hs
		973846 PAX2_HUMAN (1-391): 9.44e-97: 296: 62.20		TLE5_HUMAN (8-205): 3.48e-94: 293: 67.68
+	Hs
		641385 PAX6_HUMAN (13-391): 8.28e-85: 265: 34.21		TLE5_HUMAN (8-205): 3.48e-94: 293: 67.68
+	Hs
		620146 PAX7_HUMAN (7-387): 4.72e-83: 264: 34.65		TLE5_HUMAN (8-205): 3.48e-94: 293: 67.68
+	Ce
		105784 PAX3H_CAEEL (15-322): 4.48e-70: 224: 31.39		UNC37_CAEEL (24-773): 5.04e-95: 310: 36.86
+	Hs
		988754 PAX8_HUMAN (12-389): 2.17e-67: 221: 49.00		TLE5_HUMAN (8-205): 3.48e-94: 293: 67.68
+	Hs
		245563 PAX6_HUMAN (13-391): 8.28e-85: 265: 34.21		TBL1X_HUMAN (572-772): 8.38e-46: 174: 15.60
+	Hs
		245559 PAX7_HUMAN (7-387): 4.72e-83: 264: 34.65		TBL1X_HUMAN (572-772): 8.38e-46: 174: 15.60
+	Hs
		620138 PAX7_HUMAN (7-387): 4.72e-83: 264: 34.65		WDR5_HUMAN (658-772): 3.81e-36: 141: 21.37