HitPredict

Interactor 1: IF4A (Q02748)
Eukaryotic initiation factor 4A (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A)
Gene: eIF4A

Interactor 2: Q9VY91 (Q9VY91)
LD21074p (Programmed cell death 4, isoform A) (Programmed cell death 4, isoform B) (Programmed cell death 4, isoform C) (Programmed cell death 4, isoform D)
Gene: Pdcd4

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	23878722
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	DEAD~MA3, Helicase_C~MA3
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 403 Dm			1 509
+	Mm
		892950 IF4A1_MOUSE (4-403): 9.27e-180: 507: 72.82		PDCD4_MOUSE (1-505): 5.1e-149: 436: 37.95
+	Hs
		1051874 IF4A2_HUMAN (3-403): 3.51e-180: 508: 72.89		PDCD4_HUMAN (1-505): 1.12e-146: 430: 37.75
+	Hs
		892823 IF4A1_HUMAN (4-403): 9.27e-180: 507: 72.82		PDCD4_HUMAN (1-505): 1.12e-146: 430: 37.75
+	Hs
		757641 IF4A3_HUMAN (12-403): 3.48e-127: 374: 67.60		PDCD4_HUMAN (1-505): 1.12e-146: 430: 37.75
+	Hs
		203371 IF4A2_HUMAN (3-403): 3.51e-180: 508: 72.89		IF4G3_HUMAN (69-480): 2.08e-86: 293: 14.53
+	Hs
		203355 IF4A1_HUMAN (4-403): 9.27e-180: 507: 72.82		IF4G3_HUMAN (69-480): 2.08e-86: 293: 14.53
+	Hs
		941985 IF4A2_HUMAN (3-403): 3.51e-180: 508: 72.89		IF4G2_HUMAN (75-502): 9.92e-79: 266: 14.93
+	Hs
		892776 IF4A1_HUMAN (4-403): 9.27e-180: 507: 72.82		IF4G2_HUMAN (75-502): 9.92e-79: 266: 14.93
+	Hs
		133973 DDX3X_HUMAN (2-402): 7.76e-152: 446: 31.92		IF4G2_HUMAN (75-502): 9.92e-79: 266: 14.93
+	Dm
		247403 IF4A_DROME (1-403): 3.43e-138: 402: 100.00		O61380_DROME (5-378): 1.5e-76: 264: 11.06
+	Hs
		203341 DDX6_HUMAN (30-399): 2.58e-95: 295: 41.24		IF4G3_HUMAN (69-480): 2.08e-86: 293: 14.53
+	Hs
		979902 IF4A2_HUMAN (3-403): 3.51e-180: 508: 72.89		IF4G1_HUMAN (359-476): 7.91e-13: 73.5: 22.88
+	Hs
		892779 IF4A1_HUMAN (4-403): 9.27e-180: 507: 72.82		IF4G1_HUMAN (359-476): 7.91e-13: 73.5: 22.88
+	Mm
		892952 IF4A1_MOUSE (4-403): 9.27e-180: 507: 72.82		IF4G1_MOUSE (359-476): 6.9e-12: 70.4: 22.88
+	Hs
		133990 DDX3X_HUMAN (2-402): 7.76e-152: 446: 31.92		IF4G1_HUMAN (359-476): 7.91e-13: 73.5: 22.88
+	At
		1275773 IF4A3_ARATH (15-403): 3.53e-126: 372: 67.61		IF4G1_ARATH (353-483): 1.04e-29: 125: 31.30
+	Hs
		757578 IF4A3_HUMAN (12-403): 3.48e-127: 374: 67.60		IF4G1_HUMAN (359-476): 7.91e-13: 73.5: 22.88
+	Hs
		640441 DDX6_HUMAN (30-399): 2.58e-95: 295: 41.24		IF4G1_HUMAN (359-476): 7.91e-13: 73.5: 22.88