HitPredict

Interactor 1: MP2K1 (Q02750)
Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)
Gene: MAP2K1

Interactor 2: KSR2 (Q6VAB6)
Kinase suppressor of Ras 2 (hKSR2) (EC 2.7.11.1)
Gene: KSR2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.75 1.00 0.867

The method score is based on:

Property Details
Experiments 12975377, 32707033, 33961781
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains PK_Tyr_Ser-Thr~Pkinase
Common GO terms GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005078 - MAP-kinase scaffold activity
GO:0005524 - ATP binding
GO:0005829 - cytosol
and 2 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 393
Hs

1 950
+ Rn
+ Rn
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+ Mm
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+ Hs
+ Mm
+ Gg
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+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024