HitPredict

Interactor 1: FKBP4 (Q02790)
Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (51 kDa FK506-binding protein) (FKBP51) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (59 kDa immunophilin) (p59) (FK506-binding protein 4) (FKBP-4) (FKBP59) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed]
Gene: FKBP4

Interactor 2: TSSK2 (Q96PF2)
Testis-specific serine/threonine-protein kinase 2 (TSK-2) (TSK2) (TSSK-2) (Testis-specific kinase 2) (EC 2.7.11.1) (DiGeorge syndrome protein G) (DGS-G) (Serine/threonine-protein kinase 22B)
Gene: TSSK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	FKBP_C~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 459 Hs			1 358
+	Hs
		972577 FKBP4_HUMAN (1-459): 1.71e-150: 437: 100.00		TSSK1_HUMAN (1-336): 8.66e-147: 420: 67.61
+	Hs
		1034988 FKBP5_HUMAN (1-456): 2.91e-138: 406: 54.83		TSSK1_HUMAN (1-336): 8.66e-147: 420: 67.61
+	Hs
		1034972 FKBP5_HUMAN (1-456): 2.91e-138: 406: 54.83		TSSK2_HUMAN (1-358): 2.62e-135: 391: 100.00
+	Hs
		682173 FKBP5_HUMAN (1-456): 2.91e-138: 406: 54.83		AKT2_HUMAN (4-341): 6.4e-132: 387: 25.07
+	Hs
		1035058 FKBP5_HUMAN (1-456): 2.91e-138: 406: 54.83		AKT3_HUMAN (4-341): 4.35e-131: 385: 26.09
+	Hs
		1034987 FKBP5_HUMAN (1-456): 2.91e-138: 406: 54.83		TSSK6_HUMAN (1-273): 1.82e-79: 246: 46.35
+	Hs
		118785 AIP_HUMAN (146-416): 1.8e-50: 176: 20.12		TSSK1_HUMAN (1-336): 8.66e-147: 420: 67.61
+	Hs
		1035062 FKBP5_HUMAN (1-456): 2.91e-138: 406: 54.83		SIK3_HUMAN (12-273): 3.37e-51: 185: 37.88
+	Hs
		1034968 FKBP5_HUMAN (1-456): 2.91e-138: 406: 54.83		MARK4_HUMAN (18-272): 1.8e-51: 184: 39.15
+	Hs
		684999 STIP1_HUMAN (259-458): 6.41e-12: 69.5: 11.51		TSSK1_HUMAN (1-336): 8.66e-147: 420: 67.61
+	Hs
		684963 STIP1_HUMAN (259-458): 6.41e-12: 69.5: 11.51		TSSK2_HUMAN (1-358): 2.62e-135: 391: 100.00
+	Hs
		118784 AIP_HUMAN (146-416): 1.8e-50: 176: 20.12		TSSK6_HUMAN (1-273): 1.82e-79: 246: 46.35
+	Hs
		685124 STIP1_HUMAN (259-458): 6.41e-12: 69.5: 11.51		SIK3_HUMAN (12-273): 3.37e-51: 185: 37.88