HitPredict

Interactor 1: CREB5 (Q02930)
Cyclic AMP-responsive element-binding protein 5 (CREB-5) (cAMP-responsive element-binding protein 5) (cAMP-response element-binding protein A) (CRE-BPa)
Gene: CREB5

Interactor 2: SPRE1 (Q7Z699)
Sprouty-related, EVH1 domain-containing protein 1 (Spred-1) (hSpred1)
Gene: SPRED1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.72	0.50	0.603

Property	Details
Experiments	32296183, 32814053, unassigned1304
Identification Methods	two hybrid, two hybrid array, two hybrid pooling approach, validated two hybrid, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 508 Hs			1 444
+	Hs
		208127 CREB5_HUMAN (1-508): 3.92e-104: 322: 100.00		SPY2_HUMAN (169-433): 5.08e-63: 208: 16.61
+	Hs
		208349 CREB5_HUMAN (1-508): 3.92e-104: 322: 100.00		SPY1_HUMAN (199-433): 1.45e-56: 191: 19.69
+	Hs
		973639 CREB5_HUMAN (1-508): 3.92e-104: 322: 100.00		SPY4_HUMAN (168-435): 8.08e-54: 183: 14.97
+	Hs
		208417 CREB5_HUMAN (1-508): 3.92e-104: 322: 100.00		SPY3_HUMAN (201-435): 5.31e-43: 154: 16.79
+	Hs
		401654 JUN_HUMAN (180-452): 7.82e-29: 118: 18.31		VASP_HUMAN (10-338): 1.37e-64: 214: 19.36