HitPredict

Interactor 1: CREB5 (Q02930)
Cyclic AMP-responsive element-binding protein 5 (CREB-5) (cAMP-responsive element-binding protein 5) (cAMP-response element-binding protein A) (CRE-BPa)
Gene: CREB5

Interactor 2: ESR2 (Q92731)
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
Gene: ESR2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	29509190
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 508 Hs			1 530
+	Hs
		1243831 KMT2C_HUMAN (81-383): 3.2e-30: 127: 10.90		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		370040 KMT2C_HUMAN (81-383): 3.2e-30: 127: 10.90		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		368813 JUN_HUMAN (180-452): 7.82e-29: 118: 18.31		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Mm
		404119 JUN_MOUSE (180-452): 1.89e-29: 120: 17.90		ESR1_MOUSE (9-529): 4.88e-134: 403: 43.72
+	Hs
		368939 JUNB_HUMAN (191-447): 3.94e-24: 105: 15.14		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		377716 SC31B_HUMAN (83-412): 4.55e-33: 136: 14.45		GCR_HUMAN (3-495): 1.12e-103: 330: 22.64
+	Hs
		782595 KMT2C_HUMAN (81-383): 3.2e-30: 127: 10.90		HNF4A_HUMAN (94-502): 1.21e-107: 331: 23.30
+	Hs
		377003 JUN_HUMAN (180-452): 7.82e-29: 118: 18.31		GCR_HUMAN (3-495): 1.12e-103: 330: 22.64
+	Mm
		404101 JUN_MOUSE (180-452): 1.89e-29: 120: 17.90		GCR_MOUSE (3-495): 7.76e-103: 328: 23.23
+	Mm
		450551 JUNB_MOUSE (207-447): 4.13e-26: 111: 16.14		ERR2_MOUSE (69-499): 5.26e-107: 328: 31.11
+	Mm
		101828 F8WI37_MOUSE (105-370): 1.14e-09: 63.2: 11.31		ERR2_MOUSE (69-499): 5.26e-107: 328: 31.11
+	Mm
		1142676 KMT2C_MOUSE (105-370): 1.14e-09: 63.2: 11.31		ERR2_MOUSE (69-499): 5.26e-107: 328: 31.11
+	Hs
		487100 ATF2_HUMAN (9-503): 1.72e-64: 219: 33.87		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		487596 KMT2C_HUMAN (81-383): 3.2e-30: 127: 10.90		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Rn
		546260 JUN_RAT (180-452): 1.23e-29: 120: 17.90		ANDR_RAT (149-407): 1.07e-38: 153: 33.70
+	Hs
		487109 JUND_HUMAN (173-450): 4.53e-29: 119: 14.95		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		401304 JUN_HUMAN (180-452): 7.82e-29: 118: 18.31		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59