HitPredict

Interactor 1: DYST (Q03001)
Dystonin (230 kDa bullous pemphigoid antigen) (230/240 kDa bullous pemphigoid antigen) (Bullous pemphigoid antigen 1) (BPA) (Bullous pemphigoid antigen) (Dystonia musculorum protein) (Hemidesmosomal plaque protein)
Gene: DST

Interactor 2: NTRK2 (Q16620)
BDNF/NT-3 growth factors receptor (EC 2.7.10.1) (GP145-TrkB) (Trk-B) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Tropomyosin-related kinase B)
Gene: NTRK2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CH~PK_Tyr_Ser-Thr
Common GO terms	GO:0005829 - cytosol GO:0030424 - axon GO:0042803 - protein homodimerization activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 7570 Hs			1 822
+	Hs
		384681 DYST_HUMAN (1-7570): 0: 2600: 100.00		NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85
+	Hs
		601499 DYST_HUMAN (1-7570): 0: 2600: 100.00		FGFR2_HUMAN (120-821): 4.81e-164: 498: 23.04
+	Hs
		665392 DYST_HUMAN (1-7570): 0: 2600: 100.00		EPHA3_HUMAN (82-821): 1.09e-157: 486: 21.32
+	Hs
		665216 DYST_HUMAN (1-7570): 0: 2600: 100.00		EPHA2_HUMAN (148-822): 4.29e-141: 443: 22.43
+	Hs
		666578 DYST_HUMAN (1-7570): 0: 2600: 100.00		LTK_HUMAN (506-808): 6.29e-61: 223: 38.07
+	Rn
		88537 D3ZC56_RAT (1-7570): 0: 2414: 78.46		INSR_RAT (513-809): 7.79e-68: 247: 42.72
+	Hs
		384183 ACTN1_HUMAN (3770-4283): 1.06e-26: 123: 10.00		NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85
+	Hs
		384662 SPTB2_HUMAN (5709-7570): 7.99e-22: 108: 12.95		NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85
+	Hs
		607915 UTRN_HUMAN (264-1530): 1.26e-14: 84.8: 9.65		FGFR4_HUMAN (152-820): 3.01e-178: 534: 24.68
+	Hs
		609206 UTRN_HUMAN (264-1530): 1.26e-14: 84.8: 9.65		FGFR3_HUMAN (128-822): 1.4e-170: 514: 24.45
+	Hs
		384810 SPTN1_HUMAN (269-874): 2.44e-13: 80.3: 13.42		NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85
+	Hs
		507905 UTRN_HUMAN (264-1530): 1.26e-14: 84.8: 9.65		FGFR1_HUMAN (180-821): 3.75e-164: 498: 23.77
+	Hs
		385192 SYNE1_HUMAN (147-1832): 6.65e-10: 69: 8.83		NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85
+	Hs
		384210 DESP_HUMAN (1555-1738): 2.9e-09: 67: 28.50		NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85
+	Hs
		508011 PLEC_HUMAN (1777-1974): 1.7e-12: 77.5: 19.19		FGFR1_HUMAN (180-821): 3.75e-164: 498: 23.77
+	Rn
		102506 UTRN_RAT (359-1666): 3.64e-57: 225: 14.44		INSR_RAT (513-809): 7.79e-68: 247: 42.72
+	Hs
		968305 PLEC_HUMAN (1777-1974): 1.7e-12: 77.5: 19.19		ROR1_HUMAN (363-809): 2.11e-111: 364: 31.80
+	Hs
		885231 EPIPL_HUMAN (1651-1891): 1.02e-10: 71.7: 20.73		ROR1_HUMAN (363-809): 2.11e-111: 364: 31.80
+	Hs
		666598 GOGB1_HUMAN (1119-1866): 1.3e-10: 71.3: 6.59		LTK_HUMAN (506-808): 6.29e-61: 223: 38.07
+	Hs
		169189 SYNE1_HUMAN (147-1832): 6.65e-10: 69: 8.83		MUSK_HUMAN (193-374): 7.66e-18: 90.5: 22.92