HitPredict

Interactor 1: HHEX (Q03014)
Hematopoietically-expressed homeobox protein HHEX (Homeobox protein HEX) (Homeobox protein PRH) (Proline-rich homeodomain protein)
Gene: HHEX

Interactor 2: TLE1 (Q04724)
Transducin-like enhancer protein 1 (E(Sp1) homolog) (Enhancer of split groucho-like protein 1) (ESG1)
Gene: TLE1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.573

Property	Details
Experiments	15187083
Identification Methods	two hybrid, affinity chromatography technology, pull down
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0016055 - Wnt signaling pathway GO:0045892 - negative regulation of DNA-templated transcription GO:0140297 - DNA-binding transcription factor binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 270 Hs			1 770
+	Hs
		839732 LHX2_HUMAN (38-269): 7.77e-34: 128: 14.66		TLE1_HUMAN (1-770): 0: 594: 100.00
+	Hs
		882121 GSC_HUMAN (3-234): 4.48e-34: 125: 20.34		TLE1_HUMAN (1-770): 0: 594: 100.00
+	Hs
		679096 TLX1_HUMAN (79-252): 1.22e-32: 123: 27.32		TLE1_HUMAN (1-770): 0: 594: 100.00
+	Hs
		980663 HESX1_HUMAN (13-208): 1.22e-32: 120: 19.29		TLE1_HUMAN (1-770): 0: 594: 100.00
+	Hs
		974244 HHEX_HUMAN (1-270): 3.48e-55: 180: 100.00		TLE3_HUMAN (1-770): 3.93e-176: 526: 77.42
+	Hs
		882123 GSC_HUMAN (3-234): 4.48e-34: 125: 20.34		TLE4_HUMAN (1-770): 0: 562: 86.27
+	Hs
		679098 TLX1_HUMAN (79-252): 1.22e-32: 123: 27.32		TLE4_HUMAN (1-770): 0: 562: 86.27
+	Hs
		882122 GSC_HUMAN (3-234): 4.48e-34: 125: 20.34		TLE3_HUMAN (1-770): 3.93e-176: 526: 77.42
+	Hs
		679097 TLX1_HUMAN (79-252): 1.22e-32: 123: 27.32		TLE3_HUMAN (1-770): 3.93e-176: 526: 77.42
+	Dm
		484925 HMH2_DROME (134-260): 1.3e-36: 136: 33.07		GROU_DROME (1-770): 7.74e-141: 433: 59.79
+	Dm
		558366 UBX_DROME (16-198): 6.61e-31: 120: 19.89		GROU_DROME (1-770): 7.74e-141: 433: 59.79
+	Hs
		974247 HHEX_HUMAN (1-270): 3.48e-55: 180: 100.00		TLE5_HUMAN (1-200): 1.21e-91: 287: 64.50
+	Hs
		839735 LHX2_HUMAN (38-269): 7.77e-34: 128: 14.66		TLE5_HUMAN (1-200): 1.21e-91: 287: 64.50
+	Hs
		882124 GSC_HUMAN (3-234): 4.48e-34: 125: 20.34		TLE5_HUMAN (1-200): 1.21e-91: 287: 64.50
+	Hs
		679101 TLX1_HUMAN (79-252): 1.22e-32: 123: 27.32		TLE5_HUMAN (1-200): 1.21e-91: 287: 64.50
+	Ce
		137665 UNC4_CAEEL (93-262): 6.27e-34: 125: 22.35		UNC37_CAEEL (18-684): 5.47e-79: 267: 19.06
+	Ce
		137669 HM09_CAEEL (108-214): 5.55e-33: 119: 36.45		UNC37_CAEEL (18-684): 5.47e-79: 267: 19.06
+	Hs
		245566 TLX1_HUMAN (79-252): 1.22e-32: 123: 27.32		TBL1X_HUMAN (569-769): 5.32e-46: 175: 16.51
+	Mm
		192307 ALX4_MOUSE (56-267): 3.69e-32: 123: 16.82		TLE6_MOUSE (471-770): 9.13e-46: 174: 33.99
+	Mm
		678773 HXA2_MOUSE (30-256): 7.83e-32: 122: 20.17		TLE6_MOUSE (471-770): 9.13e-46: 174: 33.99