HitPredict

Interactor 1: MECOM (Q03112)
Histone-lysine N-methyltransferase MECOM (EC 2.1.1.367) (Ecotropic virus integration site 1 protein homolog) (EVI-1) (MDS1 and EVI1 complex locus protein) (Myelodysplasia syndrome 1 protein) (Myelodysplasia syndrome-associated protein 1)
Gene: MECOM

Interactor 2: CBX3 (Q13185)
Chromobox protein homolog 3 (HECH) (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein)
Gene: CBX3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	30462309
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1230 Hs			1 183
+	Hs
		1027271 PRD16_HUMAN (1-1230): 0: 813: 44.40		CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00
+	Hs
		203670 MECOM_HUMAN (1-1230): 0: 666: 90.02		SUV91_HUMAN (3-179): 4.73e-40: 141: 16.20
+	Hs
		974720 MECOM_HUMAN (1-1230): 0: 666: 90.02		CDY2_HUMAN (27-124): 2.81e-26: 106: 28.16
+	Hs
		800406 Z585B_HUMAN (521-1229): 2.94e-174: 535: 12.32		CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89
+	Hs
		1027143 ZN420_HUMAN (754-1229): 6.77e-157: 487: 13.40		CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00
+	Hs
		983755 ZNF91_HUMAN (631-1229): 1.08e-146: 475: 12.91		CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00
+	Hs
		64140 ZN729_HUMAN (588-1229): 1.23e-142: 466: 12.54		CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00
+	Hs
		67424 ZN850_HUMAN (6-463): 9.86e-139: 451: 20.09		CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00
+	Hs
		64135 ZN729_HUMAN (588-1229): 1.23e-142: 466: 12.54		CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89
+	Hs
		64138 ZN729_HUMAN (588-1229): 1.23e-142: 466: 12.54		CBX1_HUMAN (36-180): 1.02e-53: 170: 71.33
+	Hs
		800425 Z585A_HUMAN (2-463): 4.54e-145: 459: 20.80		CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89
+	Hs
		316190 ZN624_HUMAN (654-1229): 1.64e-162: 508: 12.96		CBX6_HUMAN (21-124): 3.3e-27: 107: 27.78
+	Hs
		1027102 ZN227_HUMAN (714-1229): 1.24e-121: 397: 14.95		CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00
+	Hs
		800409 ZN569_HUMAN (2-399): 2.13e-135: 430: 21.55		CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89
+	Hs
		563302 ZNF16_HUMAN (799-1229): 6.94e-116: 378: 14.00		CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00
+	Hs
		1027309 ZN629_HUMAN (14-493): 1.75e-106: 358: 12.40		CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00
+	Hs
		64158 ZN726_HUMAN (700-1229): 3.49e-124: 398: 14.03		CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89
+	Hs
		800447 ZN227_HUMAN (714-1229): 1.24e-121: 397: 14.95		CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89
+	Hs
		316196 ZN107_HUMAN (7-409): 8.54e-115: 378: 20.10		CBX6_HUMAN (21-124): 3.3e-27: 107: 27.78
+	Hs
		316192 ZN629_HUMAN (14-493): 1.75e-106: 358: 12.40		CBX6_HUMAN (21-124): 3.3e-27: 107: 27.78