HitPredict

Interactor 1: MECOM (Q03112)
Histone-lysine N-methyltransferase MECOM (EC 2.1.1.367) (Ecotropic virus integration site 1 protein homolog) (EVI-1) (MDS1 and EVI1 complex locus protein) (Myelodysplasia syndrome 1 protein) (Myelodysplasia syndrome-associated protein 1)
Gene: MECOM

Interactor 2: SMC1A (Q14683)
Structural maintenance of chromosomes protein 1A (SMC protein 1A) (SMC-1-alpha) (SMC-1A) (Sb1.8)
Gene: SMC1A

Species: Homo sapiens

Source: innatedb

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	30462309, 23858473
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 1230 Hs			1 1233
+	Hs
		311531 MECOM_HUMAN (1-1230): 0: 666: 90.02		SMC2_HUMAN (3-1214): 1.55e-77: 281: 17.57
+	Hs
		974684 MECOM_HUMAN (1-1230): 0: 666: 90.02		SMC4_HUMAN (4-1216): 2.64e-76: 278: 19.90
+	Hs
		974700 MECOM_HUMAN (1-1230): 0: 666: 90.02		SMC3_HUMAN (3-1229): 1.52e-70: 260: 16.00
+	Hs
		528406 MECOM_HUMAN (1-1230): 0: 666: 90.02		MYH8_HUMAN (518-1125): 3.54e-20: 99.8: 9.36
+	Hs
		974692 MECOM_HUMAN (1-1230): 0: 666: 90.02		MYH2_HUMAN (495-1125): 5.14e-20: 99: 9.49
+	Hs
		522543 MECOM_HUMAN (1-1230): 0: 666: 90.02		MYH1_HUMAN (563-1127): 7e-19: 95.6: 8.66
+	Hs
		974718 MECOM_HUMAN (1-1230): 0: 666: 90.02		MYH4_HUMAN (659-1132): 9.83e-17: 88.2: 10.58
+	Hs
		522606 MECOM_HUMAN (1-1230): 0: 666: 90.02		MYH7_HUMAN (51-420): 1.04e-10: 68.6: 13.37
+	Hs
		563781 ZNF3_HUMAN (892-1111): 1.45e-55: 202: 23.18		SMC1A_HUMAN (1-1233): 1.94e-128: 427: 100.00
+	Hs
		311471 ZNF3_HUMAN (892-1111): 1.45e-55: 202: 23.18		SMC2_HUMAN (3-1214): 1.55e-77: 281: 17.57