HitPredict

Interactor 1: MECOM (Q03112)
Histone-lysine N-methyltransferase MECOM (EC 2.1.1.367) (Ecotropic virus integration site 1 protein homolog) (EVI-1) (MDS1 and EVI1 complex locus protein) (Myelodysplasia syndrome 1 protein) (Myelodysplasia syndrome-associated protein 1)
Gene: MECOM

Interactor 2: TRI58 (Q8NG06)
E3 ubiquitin-protein ligase TRIM58 (EC 2.3.2.27) (Protein BIA2) (RING-type E3 ubiquitin transferase TRIM58) (Tripartite motif-containing protein 58)
Gene: TRIM58

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	23858473
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0042803 - protein homodimerization activity
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1230 Hs			1 486
+	Hs
		536791 MECOM_HUMAN (1-1230): 0: 666: 90.02		TRI27_HUMAN (1-474): 1.03e-142: 421: 33.79
+	Hs
		974649 MECOM_HUMAN (1-1230): 0: 666: 90.02		TRI11_HUMAN (1-472): 2.39e-143: 421: 43.37
+	Hs
		1137069 ZN658_HUMAN (498-1230): 8.11e-162: 512: 11.66		TRI39_HUMAN (7-463): 3.01e-147: 432: 37.33
+	Hs
		1128449 ZN484_HUMAN (2-430): 1.39e-140: 449: 21.62		TRI39_HUMAN (7-463): 3.01e-147: 432: 37.33
+	Hs
		1350390 ZN624_HUMAN (654-1229): 1.64e-162: 508: 12.96		TRI10_HUMAN (1-451): 4.7e-120: 361: 32.84
+	Hs
		974655 MECOM_HUMAN (1-1230): 0: 666: 90.02		ERMAP_HUMAN (259-458): 6.66e-53: 187: 49.03
+	Hs
		64163 ZN726_HUMAN (700-1229): 3.49e-124: 398: 14.03		TRI39_HUMAN (7-463): 3.01e-147: 432: 37.33
+	Hs
		536846 ZNF79_HUMAN (770-966): 5e-35: 142: 20.19		TRI27_HUMAN (1-474): 1.03e-142: 421: 33.79
+	Hs
		997546 ZN543_HUMAN (440-867): 1.71e-23: 108: 9.28		TRI39_HUMAN (7-463): 3.01e-147: 432: 37.33
+	Hs
		1238810 ZN383_HUMAN (770-935): 1.34e-18: 92.4: 17.58		TRI39_HUMAN (7-463): 3.01e-147: 432: 37.33
+	Hs
		1293686 ZN419_HUMAN (893-991): 2.37e-12: 73.2: 35.35		TRI39_HUMAN (7-463): 3.01e-147: 432: 37.33
+	Hs
		1336387 ZN214_HUMAN (179-259): 5.95e-12: 72: 16.28		TRI39_HUMAN (7-463): 3.01e-147: 432: 37.33
+	Hs
		1162543 ZN773_HUMAN (908-991): 2.23e-11: 69.7: 40.48		TRI39_HUMAN (7-463): 3.01e-147: 432: 37.33
+	Hs
		1314778 ZN416_HUMAN (908-991): 1.33e-09: 64.3: 39.29		TRI39_HUMAN (7-463): 3.01e-147: 432: 37.33
+	Hs
		1261126 ZN629_HUMAN (14-493): 1.75e-106: 358: 12.40		TRI41_HUMAN (1-44): 3.5e-11: 67.5: 39.58
+	Hs
		1261083 ZN251_HUMAN (908-1102): 2.29e-24: 112: 22.75		TRI41_HUMAN (1-44): 3.5e-11: 67.5: 39.58
+	Hs
		1162541 ZN773_HUMAN (908-991): 2.23e-11: 69.7: 40.48		TRI41_HUMAN (1-44): 3.5e-11: 67.5: 39.58
+	Hs
		1169380 ZN497_HUMAN (893-991): 5.71e-10: 65.5: 35.35		TRI41_HUMAN (1-44): 3.5e-11: 67.5: 39.58