HitPredict

Interactor 1: MECOM (Q03112)
Histone-lysine N-methyltransferase MECOM (EC 2.1.1.367) (Ecotropic virus integration site 1 protein homolog) (EVI-1) (MDS1 and EVI1 complex locus protein) (Myelodysplasia syndrome 1 protein) (Myelodysplasia syndrome-associated protein 1)
Gene: MECOM

Interactor 2: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.662

Property	Details
Experiments	35271311, 30462309, 23858473
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045892 - negative regulation of DNA-templated transcription GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1230 Hs			1 488
+	Hs
		1270453 PRD16_HUMAN (1-1230): 0: 813: 44.40		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		1038726 PRD16_HUMAN (1-1230): 0: 813: 44.40		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		974554 MECOM_HUMAN (1-1230): 0: 666: 90.02		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		1270516 PRDM4_HUMAN (909-991): 2.45e-10: 67: 36.91		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		1038803 PRDM4_HUMAN (909-991): 2.45e-10: 67: 36.91		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		1038377 ZN273_HUMAN (906-991): 8.37e-09: 61.6: 37.21		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		177403 PRDM4_HUMAN (909-991): 2.45e-10: 67: 36.91		HDAC3_HUMAN (10-431): 0: 574: 58.26
+	Hs
		599074 ZNF10_HUMAN (782-960): 1.81e-17: 89.7: 14.69		HDAC6_HUMAN (11-363): 6.94e-102: 332: 24.04