HitPredict

Interactor 1: MECOM (Q03112)
Histone-lysine N-methyltransferase MECOM (EC 2.1.1.367) (Ecotropic virus integration site 1 protein homolog) (EVI-1) (MDS1 and EVI1 complex locus protein) (Myelodysplasia syndrome 1 protein) (Myelodysplasia syndrome-associated protein 1)
Gene: MECOM

Interactor 2: TRI11 (Q96F44)
E3 ubiquitin-protein ligase TRIM11 (EC 2.3.2.27) (Protein BIA1) (RING finger protein 92) (Tripartite motif-containing protein 11)
Gene: TRIM11

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	23858473
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1230 Hs			1 468
+	Hs
		536791 MECOM_HUMAN (1-1230): 0: 666: 90.02		TRI27_HUMAN (1-464): 9.07e-139: 410: 38.28
+	Hs
		974612 MECOM_HUMAN (1-1230): 0: 666: 90.02		TRI58_HUMAN (1-463): 2.38e-138: 408: 43.62
+	Hs
		1137069 ZN658_HUMAN (498-1230): 8.11e-162: 512: 11.66		TRI39_HUMAN (7-459): 5.6e-138: 408: 40.16
+	Hs
		1128449 ZN484_HUMAN (2-430): 1.39e-140: 449: 21.62		TRI39_HUMAN (7-459): 5.6e-138: 408: 40.16
+	Hs
		974545 MECOM_HUMAN (1-1230): 0: 666: 90.02		TRI26_HUMAN (1-355): 3.97e-51: 183: 33.86
+	Hs
		1350390 ZN624_HUMAN (654-1229): 1.64e-162: 508: 12.96		TRI10_HUMAN (1-450): 1.27e-111: 339: 31.03
+	Hs
		64163 ZN726_HUMAN (700-1229): 3.49e-124: 398: 14.03		TRI39_HUMAN (7-459): 5.6e-138: 408: 40.16
+	Hs
		536846 ZNF79_HUMAN (770-966): 5e-35: 142: 20.19		TRI27_HUMAN (1-464): 9.07e-139: 410: 38.28
+	Hs
		997546 ZN543_HUMAN (440-867): 1.71e-23: 108: 9.28		TRI39_HUMAN (7-459): 5.6e-138: 408: 40.16
+	Hs
		1238810 ZN383_HUMAN (770-935): 1.34e-18: 92.4: 17.58		TRI39_HUMAN (7-459): 5.6e-138: 408: 40.16
+	Hs
		1293686 ZN419_HUMAN (893-991): 2.37e-12: 73.2: 35.35		TRI39_HUMAN (7-459): 5.6e-138: 408: 40.16
+	Hs
		1336387 ZN214_HUMAN (179-259): 5.95e-12: 72: 16.28		TRI39_HUMAN (7-459): 5.6e-138: 408: 40.16
+	Hs
		1162543 ZN773_HUMAN (908-991): 2.23e-11: 69.7: 40.48		TRI39_HUMAN (7-459): 5.6e-138: 408: 40.16
+	Hs
		1314778 ZN416_HUMAN (908-991): 1.33e-09: 64.3: 39.29		TRI39_HUMAN (7-459): 5.6e-138: 408: 40.16
+	Hs
		1261126 ZN629_HUMAN (14-493): 1.75e-106: 358: 12.40		TRI41_HUMAN (1-44): 3.16e-11: 67.5: 62.50
+	Hs
		1261083 ZN251_HUMAN (908-1102): 2.29e-24: 112: 22.75		TRI41_HUMAN (1-44): 3.16e-11: 67.5: 62.50
+	Hs
		1162541 ZN773_HUMAN (908-991): 2.23e-11: 69.7: 40.48		TRI41_HUMAN (1-44): 3.16e-11: 67.5: 62.50
+	Hs
		1169380 ZN497_HUMAN (893-991): 5.71e-10: 65.5: 35.35		TRI41_HUMAN (1-44): 3.16e-11: 67.5: 62.50