HitPredict

Interactor 1: MECOM (Q03112)
Histone-lysine N-methyltransferase MECOM (EC 2.1.1.367) (Ecotropic virus integration site 1 protein homolog) (EVI-1) (MDS1 and EVI1 complex locus protein) (Myelodysplasia syndrome 1 protein) (Myelodysplasia syndrome-associated protein 1)
Gene: MECOM

Interactor 2: ZN148 (Q9UQR1)
Zinc finger protein 148 (Transcription factor ZBP-89) (Zinc finger DNA-binding protein 89)
Gene: ZNF148

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	23858473
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	zf-C2H2~zf-C2H2
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0003700 - DNA-binding transcription factor activity GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0045892 - negative regulation of DNA-templated transcription and 1 others more... GO:0046872 - metal ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1230 Hs			1 794
+	Mm
		56945 PRD16_MOUSE (1-1230): 0: 834: 44.07		ZN148_MOUSE (1-794): 0: 815: 97.61
+	Hs
		974708 MECOM_HUMAN (1-1230): 0: 666: 90.02		ZN281_HUMAN (196-769): 1.05e-135: 426: 29.51
+	Hs
		983758 ZNF91_HUMAN (631-1229): 1.08e-146: 475: 12.91		ZKSC8_HUMAN (43-386): 8.58e-79: 266: 19.77
+	Hs
		64162 ZN726_HUMAN (700-1229): 3.49e-124: 398: 14.03		ZN430_HUMAN (13-298): 1.3e-95: 311: 21.28
+	Hs
		563267 ZN708_HUMAN (748-1000): 8.06e-71: 250: 19.52		ZN543_HUMAN (57-461): 4.52e-131: 404: 17.87
+	Hs
		1078433 ZN629_HUMAN (14-493): 1.75e-106: 358: 12.40		ZKSC8_HUMAN (43-386): 8.58e-79: 266: 19.77
+	Hs
		563519 ZN624_HUMAN (654-1229): 1.64e-162: 508: 12.96		ZNF22_HUMAN (196-276): 2.39e-16: 80.9: 39.51
+	Hs
		1193060 ZN624_HUMAN (654-1229): 1.64e-162: 508: 12.96		ZN467_HUMAN (194-274): 1.88e-12: 72.8: 38.27
+	Hs
		264766 ZN254_HUMAN (10-316): 9.39e-87: 297: 15.84		ZN479_HUMAN (53-328): 3.74e-74: 252: 22.89
+	Hs
		1193010 ZN845_HUMAN (541-1230): 4.09e-149: 476: 12.62		ZN467_HUMAN (194-274): 1.88e-12: 72.8: 38.27
+	Hs
		1192998 ZN721_HUMAN (646-1229): 1.32e-148: 472: 13.18		ZN467_HUMAN (194-274): 1.88e-12: 72.8: 38.27
+	Hs
		563492 ZN808_HUMAN (550-1229): 2.62e-143: 458: 12.35		ZNF22_HUMAN (196-276): 2.39e-16: 80.9: 39.51
+	Hs
		1192991 ZFP62_HUMAN (626-1229): 5.12e-144: 460: 11.37		ZN467_HUMAN (194-274): 1.88e-12: 72.8: 38.27
+	Hs
		563270 ZN708_HUMAN (748-1000): 8.06e-71: 250: 19.52		ZKSC8_HUMAN (43-386): 8.58e-79: 266: 19.77
+	Hs
		563279 ZNF16_HUMAN (799-1229): 6.94e-116: 378: 14.00		ZNF7_HUMAN (284-529): 7.34e-17: 87.2: 10.53
+	Hs
		1193063 ZN107_HUMAN (7-409): 8.54e-115: 378: 20.10		ZN467_HUMAN (194-274): 1.88e-12: 72.8: 38.27
+	Hs
		563308 ZNF16_HUMAN (799-1229): 6.94e-116: 378: 14.00		ZN467_HUMAN (194-274): 1.88e-12: 72.8: 38.27
+	Hs
		1193061 ZN629_HUMAN (14-493): 1.75e-106: 358: 12.40		ZN467_HUMAN (194-274): 1.88e-12: 72.8: 38.27
+	Hs
		264764 ZN254_HUMAN (10-316): 9.39e-87: 297: 15.84		ZN467_HUMAN (194-274): 1.88e-12: 72.8: 38.27
+	Hs
		1193025 ZN184_HUMAN (966-1230): 1.06e-71: 257: 13.98		ZN467_HUMAN (194-274): 1.88e-12: 72.8: 38.27