HitPredict - High confidence protein-protein interactions

Interactor 1: KMT2A (Q03164)
Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]
Gene: KMT2A

Interactor 2: KMT2A (Q03164)
Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]
Gene: KMT2A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	1.00	0.961

Property	Details
Experiments	11313484, 10656681, 12482972, 12393701, 24235145, 20153263
Identification Methods	two hybrid, pull down, affinity chromatography technology, enzymatic study, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	FYRC~FYRN, PHD~PHD, SET~SET, zf-CXXC~zf-CXXC
Common GO terms	GO:0003680 - minor groove of adenine-thymine-rich DNA binding GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol and 34 others more... GO:0006915 - apoptotic process GO:0008270 - zinc ion binding GO:0008542 - visual learning GO:0009791 - post-embryonic development GO:0009952 - anterior/posterior pattern specification GO:0032259 - methylation GO:0032922 - circadian regulation of gene expression GO:0035097 - histone methyltransferase complex GO:0035162 - embryonic hemopoiesis GO:0035640 - exploration behavior GO:0035864 - response to potassium ion GO:0036211 - protein modification process GO:0042800 - histone H3K4 methyltransferase activity GO:0042803 - protein homodimerization activity GO:0045064 - T-helper 2 cell differentiation GO:0045322 - unmethylated CpG binding GO:0045815 - transcription initiation-coupled chromatin remodeling GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0048144 - fibroblast proliferation GO:0048147 - negative regulation of fibroblast proliferation GO:0048172 - regulation of short-term neuronal synaptic plasticity GO:0048536 - spleen development GO:0048873 - homeostasis of number of cells within a tissue GO:0051899 - membrane depolarization GO:0060216 - definitive hemopoiesis GO:0065003 - protein-containing complex assembly GO:0070577 - lysine-acetylated histone binding GO:0071339 - MLL1 complex GO:0071560 - cellular response to transforming growth factor beta stimulus GO:0090310 - negative regulation of DNA methylation-dependent heterochromatin formation GO:0106363 - protein-cysteine methyltransferase activity GO:0140945 - histone H3K4 monomethyltransferase activity GO:0140999 - histone H3K4 trimethyltransferase activity
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1	3969
Hs

1	3969

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024